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Apolipoprotein and lipid abnormalities in chronic liver failure BJMBR
Spósito,A.C.; Vinagre,C.G.; Pandullo,F.L; Mies,S.; Raia,S.; Ramires,J.A.F..
Total serum lipids, as well as apolipoproteins A-I (apo A-I) and B (apo B), were determined in 74 patients with chronic liver failure without cholestasis and in 82 normal subjects. The VLDL, LDL and HDL lipid fractions were reduced in the liver failure group by 36%, 24% and 46%, respectively (P<0.001). Apolipoproteins A-I and B were also reduced by 26% and 25%, respectively (P<0.001). However, the reduction of HDL cholesterol (HDLc) was more pronounced than that of apo A-I and the HDLc:apo A-I ratio was significantly lower in the liver failure group. After separating these patients into groups with plasma albumin lower than 3.0, between 3.0 and 3.5, and higher than 3.5 g/dl, the HDLc:apo A-I ratio was proportional to plasma albumin, but the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic liver disease; Liver failure; Apolipoprotein A; Apolipoprotein B; LCAT; HDL cholesterol; VLDL cholesterol; Lipid metabolism.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100004
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Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS) BJMBR
Fuzikawa,A.K.; Peixoto,S.V.; Taufer,M.; Moriguchi,E.H.; Lima-Costa,M.F..
Apolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with arterial hypertension is controversial. The objective of this study was to examine the association between ApoE polymorphism and prevalent hypertension in a large unselected population of older adults. Participants from the baseline of the Bambuí Health Aging Study whose ApoE genes had been genotyped were selected for this study (N = 1406, aged 60-95 years). These subjects represented 80.7% of the total elderly residents in Bambuí city, MG, Brazil. Hypertension was defined as a systolic blood pressure ³140 mmHg and/or a diastolic blood pressure ³90 mmHg, or the use of anti-hypertensive medication. The exposure variable was the ApoE genotype as follows: e3 carriers,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apolipoprotein E; Hypertension; Low-density lipoprotein cholesterol; Triglycerides; Lipid metabolism.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200002
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Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice BJMBR
Marques,C.M.M.; Motta,V.F.; Torres,T.S.; Aguila,M.B.; Mandarim-de-Lacerda,C.A..
C57BL/6 mice develop signs and symptoms comparable, in part, to the human metabolic syndrome. The objective of the present study was to evaluate the effects of exercise training on carbohydrate metabolism, lipid profile, visceral adiposity, pancreatic islet alterations, and nonalcoholic fatty liver disease in C57BL/6 mice. Animals were fed one of two diets during an 8-week period: standard (SC, N = 12) or very high-fat (HF, N = 24) chow. An exercise training protocol (treadmill) was then established and mice were divided into SC and HF sedentary (SC-Sed, HF-Sed), exercised groups (SC-Ex, HF-Ex), or switched from HF to SC (HF/SC-Sed and HF/SC-Ex). HF/HF-Sed mice had the greatest body mass (65% more than SC/SC-Sed; P < 0.0001), and exercise reduced it by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obesity; Lipid metabolism; Metabolic syndrome; Aerobic training; Fatty liver; Stereology.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500008
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Cholesterol-Lowering and Liver-Protective Effects of Cooked and Germinated Mung Beans (Vigna radiata L.). Repositório Alice
LOPES, L. A. R.; MARTINS, M. do C. de C. e; FARIAS, L. M. de; BRITO, A. K. da S.; LIMA, G. de M.; CARVALHO, V. B. L. de; PEREIRA, C. F. de C.; CONDE JÚNIOR, A. M.; SALDANHA, T.; ARÊAS, J. A. G.; SILVA, K. J. D. e; FROTA, K. de M. G..
We investigated the hypocholesterolemic and liver-protective effects of cooked and germinated whole mung beans. Hamsters were fed for 28 days on diets rich in saturated fatty acids and cholesterol, differing only in protein source (20%): casein, cooked whole mung bean, and germinated mung bean. After 28 days, we found reduced plasma concentrations of total cholesterol and non-HDL cholesterol, increased faecal cholesterol excretion, and reduced levels of asparagine aminotransferase and alanine aminotransferase enzymes in the liver. Reduction in hepatic lipid deposition was observed between each of the mung bean groups relative to the casein group. In addition, the animals of the geminated mung bean group showed a lack of inflammatory infiltrate and better...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Metabolismo lipídico; Doença cardiovascular; Proteína; Germinação; Vigna; Germination; Lipid metabolism; Cardiovascular diseases; Fatty liver.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1106177
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Dietary canitine maintains energy reserves and delays fatigue of exercised african catfish (Clarias gariepinus) fed high fat diets Scientia Agricola
Ozório,Rodrigo; Van Ginneken,Vincent; van den Thillart,Guido; Verstegen,Martin; Verreth,Johan.
Lipids, together with proteins, are traditionally considered as primary fuels during aerobic swimming. The effects of dietary fat and carnitine supplements and exercise on the energy metabolism of juvenile fish were investigated. One hundred African catfish (Clarias gariepinus) were fed four isonitrogenous diets containing a fat level of 100 or 190 g kg-1 diet and one of the two levels of carnitine (15 and 1000 mg kg-1). Fish grew from 61 to 162 g in 10 wk. Thereafter, 6 fish per group swam vigorously for 3 h and the results were compared with unexercised groups. Fish receiving 1,000 mg carnitine accumulated 2- to 3-fold more carnitine than fish receiving 15 mg carnitine. Plasma acyl-carnitine level was affected by an interaction between dietary treatment...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lipid metabolism; Catfish; Stress; Intensive aquaculture; Exhaustive swimming.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162005000300002
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Efeito da somatotropina (bST) e de B-adrenergicos na lipolise e lipase sensivel a hormonio em vacas em lactacao. Repositório Alice
LANNA, D.P.D.; HOUSEKNECHT, K.L.; BAUMAN, D.E..
Estudou-se o efeito da somatotropina (bST) na lipase sensivel a hormonio (HSL), a enzima reguladora da lipose. Cinco vacas receberam injecoes diarias de 40 mg de bST ou veiculo, em delineamento de reversao simples. A bST aumentou a producao de leite (19,2 para 27,9 kg/d; P<0,01) sem alterar o consumo de alimento; consequentemente as vacas passaram de balanco energetico positivo (3,6 Mcal/d) para negativo (-2,6 Mcal/d; P<0,01) e o teor de gordura aumentou (3,6 para 4,2%; (P<0,01). As atividades da HSL basal, ativada por dbcAMP e por dbcAMP+PKA, nao foram alteradas pela bST (P>0,10). A bST nao alterou (P>0,10) a atividade ou o grau de ativacao da HSL de explantes incubados com isoproterenol (10.5M) e adenosina deaminase (0,75 U/m). Embora o...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Bovinos; Enzima reguladora; Metabalismo de gorduras; Tecido adiposo; Bovine; Regulating enzyme; Lipid metabolism; Adipose tissue.
Ano: 1996 URL: http://www.alice.cnptia.embrapa.br/handle/doc/104052
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Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women Genet. Mol. Biol.
Oliveira,Jéssica de; Tureck,Luciane Viater; Santos,Willian dos; Saliba,Louise Farah; Schenknecht,Caroline Schovanz; Scaraboto,Débora; Souza,Ricardo Lehtonen R.; Furtado-Alle,Lupe.
Abstract Butyrylcholinesterase (BChE) activity and polymorphisms in its encoding gene had previously been associated with metabolic traits of obesity. This study investigated the association of three single nucleotide polymorphisms (SNPs) in the BCHE gene: -116G > A (rs1126680), 1615GA (rs1803274), 1914A < G (rs3495), with obesity and lipid metabolism markers, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) levels, and BChE enzymatic activity in obese (BMI≥30/n = 226) and non-obese women (BMI < 25/n = 81). BCHE SNPs genotyping was obtained by TaqMan allelic discrimination assay and by RFLP-PCR. Plasmatic BChE activity was measured using...
Tipo: Info:eu-repo/semantics/article Palavras-chave: BCHE gene; Obesity; Lipid metabolism; Polymorphisms.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300408
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Effect of Cottonseed Meal Fermented with Yeast on the Lipid-related Gene Expression in Broiler Chickens Rev. Bras. Ciênc. Avic.
Nie,CX; Zhang,WJ; Ge,WX; Liu,YF; Wang,YQ; Liu,JC.
ABSTRACT Fermented cottonseed meal (FCSM) is widely used in poultry diets in China. This study was conducted to investigate the effect of FCSM on lipid-related gene expression in broilers. Initially, 180 broiler chickens (21-days-old, equal number of males and females) were randomly divided into three groups, with six pens per group and 10 birds per pen. The chickens in the control group were fed a diet containing unfermented cottonseed meal, and those in the treatment groups were fed with diets including either CSM fermented by Candida tropicalis (Ct group) or CSM fermented by Candida tropicalis plus Saccharomyces cerevisae (Ct-Sc group) until 64 days old. The results revealed that, compared with the control group (p<0.05), the mRNA expression of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fermented cottonseed meal; Fermented feed; Lipid metabolism; Gene expression; Broilers.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2015001000057
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Effect of Ultra-fine Traditional Chinese Medicine Compounds on Regulation of Lipid Metabolism and Reduction in Egg Cholesterol of Laying Hens Rev. Bras. Ciênc. Avic.
Song,Y; Zhu,J; Wang,T; Zhang,C; Yang,F; Guo,X; Liu,P; Cao,H; Hu,G.
ABSTRACT This study has the objective of investigating the effects of traditional Chinese medicine prescriptions (TCM) on serum lipid, abdominal and hepatic fat percentage, cholesterol content in eggs, and mRNA expression of genes apoA I and apoB100. One hundred and thirty five healthy (300-day-old) layers were randomly assigned to three treatments. The hens in control group were fed with the basal diet. The hens in the experimental groups (TCM 1 and TCM 2) were fed with the basal diet supplemented with 1% TCM 1 and 1% TCM 2 respectively over a period of 60 days. Laying performance and the serum parameters relevant to fat metabolism were measured. The results showed that no significant differences were found in average daily feed intake and egg weight...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Laying hens; Cholesterol; Traditional Chinese medicine; Lipid metabolism; Apolipoprotein..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2018000100153
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Effects of high-intensity intermittent training on carnitine palmitoyl transferase activity in the gastrocnemius muscle of rats BJMBR
Carnevali Jr,L.C.; Eder,R.; Lira,F.S.; Lima,W.P.; Gonçalves,D.C.; Zanchi,N.E.; Nicastro,H.; Lavoie,J.M.; Seelaender,M.C.L..
We examined the capacity of high-intensity intermittent training (HI-IT) to facilitate the delivery of lipids to enzymes responsible for oxidation, a task performed by the carnitine palmitoyl transferase (CPT) system in the rat gastrocnemius muscle. Male adult Wistar rats (160-250 g) were randomly distributed into 3 groups: sedentary (Sed, N = 5), HI-IT (N = 10), and moderate-intensity continuous training (MI-CT, N = 10). The trained groups were exercised for 8 weeks with a 10% (HI-IT) and a 5% (MI-CT) overload. The HI-IT group presented 11.8% decreased weight gain compared to the Sed group. The maximal activities of CPT-I, CPT-II, and citrate synthase were all increased in the HI-IT group compared to the Sed group (P < 0.01), as also was gene...
Tipo: Info:eu-repo/semantics/article Palavras-chave: High-intensity intermittent training; Lipid metabolism; Carnitine palmitoyl transferase.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000800013
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Genome-wide association study for backfat thickness in Canchim beef cattle using Random Forest approach. Repositório Alice
MOKRY, F. B.; HIGA, R. H.; MUDADU, M. de A.; LIMA, A. O. de; MEIRELLES, S. L. C.; SILVA, M. V. G. B. da; CARDOSO, F. F.; OLIVEIRA, M. M. de; URBINATI, I.; NICIURA, S. C. M.; TULLIO, R. R.; ALENCAR, M. M. de; REGITANO, L. C. de A..
Background: Meat quality involves many traits, such as marbling, tenderness, juiciness, and backfat thickness, all of which require attention from livestock producers. Backfat thickness improvement by means of traditional selection techniques in Canchim beef cattle has been challenging due to its low heritability, and it is measured late in an animal?s life. Therefore, the implementation of new methodologies for identification of single nucleotide polymorphisms (SNPs) linked to backfat thickness are an important strategy for genetic improvement of carcass and meat quality. Results: The set of SNPs identified by the random forest approach explained as much as 50% of the deregressed estimated breeding value (dEBV) variance associated with backfat thickness,...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Polimorfismo de nucleotídeo único; Gado de corte; Metabolismo lipídico; Aprendizado de máquina; Inteligência artificial; Machine learning; Tecido adiposo subcutâneo; Single nucleotide polymorphism; Beef cattle; Lipid metabolism; Artificial intelligence; Subcutaneous fat.
Ano: 2013 URL: http://www.alice.cnptia.embrapa.br/handle/doc/977539
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High Postprandial Triglycerides Serum Levels: Is Obesity a Good Predictor? Anais da ABC (AABC)
NOGAROTO,VIVIANE; RODRIGUES,MARCOS R.S.; VICARI,MARCELO R.; ALMEIDA,MARA C. DE; MILLÉO,FÁBIO Q.; SANTOS,FÁBIO A. DOS; ARTONI,ROBERTO F..
The aim of this study was to analyze the correlation between triglyceride (TG) serum levels in obese and non-obese patients in a simulated postprandial state. Both groups showed TG levels < 150 mg/dL when fasting. After 12 h fasting, the subjects ingested a lipid overload diet and blood samples were collected. The variation between fasting and the postprandial TG peak levels were analyzed. The peak of postprandial TG levels occurred 4 h after the lipid overload in both groups. When the subjects were not fasting, the majority of non-obese subjects remained within the range of normal TG values, but the values for the obese group remained elevated. There was a significant correlation between Body Mass Index (BMI) and TG at each time point until 2 h after...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Body mass index; Lipid metabolism; Risk factor; ROC curve.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100437
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Host Cholesterol Synthesis Contributes to Growth of Intracellular Toxoplasma gondii in Macrophages OAK
NISHIKAWA, Yoshifumi; IBRAHIM, Hany M.; KAMEYAMA, Kyohko; SHIGA, Ikumi; HIASA, Jun; XUAN, Xuenan; 西川, 義文; 玄, 学南.
The intracellular protozoan Toxoplasma gondii lacks the ability to synthesize sterol and scavenges cholesterol from the lowdensity lipoprotein receptor (LDLR) pathway of its host to facilitate replication. Sterol biosynthesis inhibitors, however, have a demonstrated anti-Toxoplasma effect. In this study, we examined the host mevalonate pathway as a novel source of cholesterol for T. gondii and its effects on parasite growth in macrophages. Parasite growth did not significantly change in the absence of LDLR or when LDL was exogenously supplemented. Lovastatin and compactin, both inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase in the mevalonate pathway, significantly inhibited T. gondii growth in both wild-type and LDLR-knockout macrophages....
Palavras-chave: Cholesterol; Lipid metabolism; Macrophage; Parasitology; Toxoplasma gondii.
Ano: 2011 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3583
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Influence of dietary fat sources and conjugated fatty acid on egg quality, yolk cholesterol, and yolk fatty acid composition of laying hens R. Bras. Zootec.
Keum,Moung-Cheul; An,Byoung-Ki; Shin,Kyoung-Hoon; Lee,Kyung-Woo.
ABSTRACT This study was conducted to investigate the effects of dietary fats (tallow [TO] or linseed oil [LO]) or conjugated linoleic acid (CLA), singly or in combination, on laying performance, yolk lipids, and fatty acid composition of egg yolks. Three hundred 50-week-old laying hens were given one of five diets containing 2% TO; 1% TO + 1% CLA (TO/CLA); 2% LO; 1% LO + 1% CLA (LO/CLA); and 2% CLA (CLA). Laying performance, egg lipids, and serum parameters were not altered by dietary treatments. Alpha-linolenic acid or long-chain ω-3 fatty acids including eicosapentaenoic and docosahexaenoic acids were elevated in eggs of laying hens fed diets containing LO (i.e., LO or LO/CLA groups) compared with those of hens fed TO-added diets. Dietary CLA, alone or...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lipid metabolism; Linseed oil; Ω-3 fatty acids.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982018000100521
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Nutritional characteristics of amazonian fish fat (Colossoma macropomum) and its effect on lipid metabolism of rats fed hypercholesterolemic diets Ciênc. Tecnol. Aliment.
Sousa,Raimundo Vicente de; Santos,Paulo César Ferreira; Bambirra,Eduardo Alues; Vieira,Enio Cardillo; Alvarez-Leite,Jacqueline Isaura.
The effects of fat from tambaqui (Colossoma macropomum), an Amazonian fish, on some nutritional and lipid parameters in rats were evaluated. Weaned Wistar rats were fed for 6 weeks with hypercholesterolemic diets containing 7.5% of soybean oil (SO), cod liver oil (CO), lard (LA), or tambaqui fat (TF). Food consumption, weight gain, and food conversion were measured weekly. Plasma triglycerides was determined at the beginning and on the 6th week of experiment. Plasma cholesterol was determined at 0, 2, 4 and 6 weeks. After the sacrifice, hepatic lipids (triglycerides and cholesterol) and plasma triglycerides, total cholesterol and HDL fractions were determined. Food consumption and weight gain were the same for all groups. There were no differences in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dietary fish oil; Cholesterol; Rats; Lipid metabolism.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612002000100016
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TP53 codon 72 polymorphism as a risk factor for cardiovascular disease in a Brazilian population BJMBR
Smith,M.A.C.; Silva,M.D.A.; Cendoroglo,M.S.; Ramos,L.R.; Araujo,L.M.Q.; Labio,R.W.; Burbano,R.R.; Chen,E.S.; Payão,S.L.M..
TP53, a tumor suppressor gene, has a critical role in cell cycle, apoptosis and cell senescence and participates in many crucial physiological and pathological processes. Identification of TP53 polymorphism in older people and age-related diseases may provide an understanding of its physiology and pathophysiological role as well as risk factors for complex diseases. TP53 codon 72 (TP53:72) polymorphism was investigated in 383 individuals aged 66 to 97 years in a cohort from a Brazilian Elderly Longitudinal Study. We investigated allele frequency, genotype distribution and allele association with morbidities such as cardiovascular disease, type II diabetes, obesity, neoplasia, low cognitive level (dementia), and depression. We also determined the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiovascular risk factors; HDL; Lipid metabolism; TP53 polymorphism codon 72; Age-related diseases; Elderly cohort.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100007
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