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Acute toxicity of commercial atrazine in Piaractus mesopotamicus: histopathological, ultrastructural, molecular, and genotoxic evaluation. Repositório Alice
PAIVA, P. P. de; DELCORSO, M. C.; MATHEUS, V. A.; QUEIROZ, S. C. do N. de; COLLARES-BUZATO, C. B.; ARANA, S..
The aim of this work was to evaluate the sensitivity of Pacu fingerlings (Piaractus mesopotamicus) by measuring the effects of median lethal concentration (LC50) of atrazine (ATZ - 28.58 mg/L) after acute exposure (up to 96 h). The fish were exposed to the LC50 of ATZ for 96 h (28.58 mg/L) in a static system. During the experiment, the fingerlings were randomly distributed in four glass tanks (50 L) containing dechlorinated water. Four glass tanks were for the control group, and four were for the ATZ-exposed group (n=4 per glass tank), given a total number of 16 animals tested per group. The genotoxicity was evaluated by micronucleus (MN) test in erythrocytes from peripheral blood. Qualitative and semi-quantitative histopathological analyses, and also...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Brazilian ichthyofauna; Kidney lesions; Liver lesions; Micronucleus test; Pacu; Herbicida; Toxidez; Poluição da água; Piaractus mesopotamicus; Water pollution; Atrazine; Oxidative stress; Nephrotoxicity; Hepatotoxicity.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1080546
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Chronic ethanol consumption in mice does not induce DNA damage in somatic or germ cells, evaluated by the bone marrow micronucleous assay and the dominant lethal mutation assay Biol. Res.
Ellahueñe,Manuel F; Pérez-Alzola,L Patricia; Olmedo,M Isabel.
Although alcohol is known to be a carcinogen for humans, ethanol-genotoxicity studies are incomplete. Ethanol seems not to be a bacterial mutagen, but the results are conflicting in rodent assays. We investigate the genotoxicity in the bone marrow micronucleus (MN) test and in the dominant lethal mutation (DLM) assay using two long-term ethanol exposure protocols. In the MN test, mice consumed three doses (5, 10 and 15% v/v) for 32 weeks. MN induction was compared to two control groups of 5- and 38-week-old mice (the ages of the treated mice when the treatment was initiated and when they were killed, respectively). For the three groups treated with ethanol there was no significant increase in MN induction as compared to the first control group, but...
Tipo: Journal article Palavras-chave: Dominant lethal mutation; Ethanol; Genotoxicity; Micronucleus test.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100004
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Effect of watercress on induced DNA damage, DNA repair and p-glycoprotein activity in human lymphocytes JBAG
Casanova,N.A; Wagner,M.L; López Nigro,M.M; Carballo,M.A.
Cruciferae vegetables are widely studied due to their potential anticarcinogenic properties. In the present work we analyzed the antigenotoxic effect of watercress (Nasturtium officinale, W. Aiton), a member of this family. The vegetal was processed, and the juice obtained was evaluated in relation with genetic material protection and DNA repair capacity against two deleterious agents: mitomycin C and hydrogen peroxide. The antigenotoxic properties were analyzed through cytokinesis block micronucleus test and comet assay (standard and with endonuclease), respectively. Besides, we tested the functionality of P-glycoprotein in human lymphocytes exposed to the whole extract. Watercress had no effect on mitomycin cytostatic effect (p>0.05) and although...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chemopreventive effects; Comet assay; Micronucleus test; Transporters; Nasturtium officinale.
Ano: 2014 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332014000300005
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