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Caractérisation et diversité des mécanismes du syndrome de mortalité affectant les juvéniles de Crassostrea gigas ArchiMer
Lucasson, Aude.
nfectious diseases are very often explored using reductionist approaches, despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with complex etiology therefore remain misunderstood. In this thesis, by developing a holistic approach to tackle the complexity of the interaction, (i) we deciphered the complex intra-host interactions underlying the Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide and (ii) we validated this mechanism in different infectious environments and oyster genotypes. Using ecologically realistic experimental infections combined with thorough molecular (metabarcoding, transcriptomics,...
Tipo: Text Palavras-chave: Maladie multifactorielle; Pathosystème; Huîtres; Transcriptome; Structure du microbiote; Séquençage haut débit; Microbiota structure; Ngs; Multifactorial diseases; Pathosystem; Oysters.
Ano: 2018 URL: https://archimer.ifremer.fr/doc/00498/60998/64415.pdf
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Effects of a PPARG gene variant on obesity characteristics in Brazil BJMBR
Mattevi,V.S.; Zembrzuski,V.M.; Hutz,M.H..
The contribution of genetic factors to the development of obesity has been widely recognized, but the identity of the genes involved has not yet been fully clarified. Variation in genes involved in adipocyte differentiation and energy metabolism is expected to have a role in the etiology of obesity. We assessed the potential association of a polymorphism in one candidate gene, peroxisome proliferator-activated receptor-gamma (PPARGg), involved in these pathways and obesity-related phenotypes in 335 Brazilians of European descent. All individuals included in the sample were adults. Pregnant women, as well as those individuals with secondary hyperlipidemia due to renal, liver or thyroid disease, and diabetes, were not invited to participate in the study; all...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obesity; PPARG gene; Genetic susceptibility; Multifactorial diseases.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700006
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