Sabiia Seb
PortuguêsEspañolEnglish
Embrapa
        Busca avançada

Botão Atualizar


Botão Atualizar

Ordenar por: RelevânciaAutorTítuloAnoImprime registros no formato resumido
Registros recuperados: 11
Primeira ... 1 ... Última
Imagem não selecionada

Imprime registro no formato completo
Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite) Anais da ABC (AABC)
SILVA,VICTOR D.A.; CUEVAS,CARLOS; MUÑOZ,PATRICIA; VILLA,MONICA; AHUMADA-CASTRO,ULISES; HUENCHUGUALA,SANDRO; SANTOS,CLEONICE C. DOS; ARAUJO,FILLIPE M. DE; FERREIRA,RAFAEL S; SILVA,VANESSA B. DA; SILVA,JULIANA H.C. E; SOARES,ÉRICA N.; VELOZO,EUDES S.; SEGURA-AGUILAR,JUAN; COSTA,SILVIA L..
ABSTRACT Prosopis juliflora is a shrub that has been used to feed animals and humans. However, a synergistic action of piperidine alkaloids has been suggested to be responsible for neurotoxic damage observed in animals. We investigated the involvement of programmed cell death (PCD) and autophagy on the mechanism of cell death induced by a total extract (TAE) of alkaloids and fraction (F32) from P. juliflora leaves composed majoritary of juliprosopine in a model of neuron/glial cell co-culture. We saw that TAE (30 µg/mL) and F32 (7.5 µg/mL) induced reduction in ATP levels and changes in mitochondrial membrane potential at 12 h exposure. Moreover, TAE and F32 induced caspase-9 activation, nuclear condensation and neuronal death at 16 h exposure. After 4 h,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Programmed cell death; Autophagy; Glial cells; Neurons; Piperidine alkaloids; Prosopis juliflora..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100247
Imagem não selecionada

Imprime registro no formato completo
Controle neuromodulateur et flexibilite d'expression d'un reseau neuronal central: Le systeme pylorique des crustaces decapodes ArchiMer
Nagy, F; Cazalets, J; Moulins, M.
In decapod Crustacea, the rhythmic activity of the pyloric filter is programmed within a network of 14 neurons in the stomatogastric nervous system. The pyloric network activity is underlied by both the endogenous regenerative properties of its neurons and the organization of their synaptic connections. Both factors are controlled by central modulatory neurons. Two of these neurons were identified, the APM neuron, which induces, and the PS neuron, which suppresses, the regenerative properties of pyloric neurons. APM can start and PS can stop the rhythmic pyloric activity, but both of them can also change its expression. Because of this control, the pyloric network can produce several types of motor pattern.
Tipo: Text Palavras-chave: Crustacea; Alimentary organs; Neurons; Neurophysiology.
Ano: 1987 URL: http://archimer.ifremer.fr/doc/1987/acte-1386.pdf
Imagem não selecionada

Imprime registro no formato completo
Differential Effect of the Route of Inoculation of Rabies Virus on NeuN Immunoreactivity in the Cerebral Cortex of Mice International Journal of Morphology
Rengifo,Aura Caterine; Umbarila,Vanessa Jazmin; Garzón,Mary Janeth; Torres-Fernández,Orlando.
Rabies is a lethal disease caused by a neurotropic virus that produces inconspicuous morphological changes hardly observable with conventional histopathology. The fatal outcome caused by rabies could be attributed to specific biochemical changes that severely impact neuronal function. The neuronal nuclear protein (NeuN) has become a widely used neuronal marker for the research and the histopathological diagnosis of nervous system diseases. To evaluate the distribution of the protein NeuN in the motor cortex of normal and rabies-infected mice adult ICR mice were inoculated with rabies virus either intramuscularly or intracerebrally. Rabies-infected mice were sacrificed at the terminal stage of the disease. Control mice were also euthanized at the same age....
Tipo: Journal article Palavras-chave: Rabies; NeuN; Cerebral cortex; Mouse; Immunohistochemistry; Neurons.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400031
Imagem não selecionada

Imprime registro no formato completo
Horizontal projections of area 17 in Cebus monkeys: metric features, and modular and laminar distribution BJMBR
Amorim,A.K.J.; Picanço-Diniz,C.W..
Metric features and modular and laminar distributions of intrinsic projections of area 17 were studied in Cebus apella. Anterogradely and retrogradely labeled cell appendages were obtained using both saturated pellets and iontophoretic injections of biocytin into the operculum. Laminar and modular distributions of the labeled processes were analyzed using Nissl counterstaining, and/or cytochrome oxidase and/or NADPH-diaphorase histochemistry. We distinguished three labeled cell types: pyramidal, star pyramidal and stellate cells located in supragranular cortical layers (principally in layers IIIa, IIIb <!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">a</font>, IIIb ß and IIIc). Three distinct axon terminal morphologies were found, i.e.,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: V1 intracortical projections; Neurons; Axon terminals; Visual cortex; Primate.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200018
Imagem não selecionada

Imprime registro no formato completo
Immunohistochemistry of GluR1 subunits of AMPA receptors of rat cerebellar nerve cells Biocell
Castejón,Orlando J.; Dailey,Michael E..
The localization of GluR1 subunits of ionotropic glutamate receptors in the glial cells and inhibitory neurons of cerebellar cortex and their association with the climbing and parallel fibers, and basket cell axons were studied. Samples of P14 and P21 rat cerebellar cortex were exposed to a specific antibody against GluR1 subunit(s) of AMPA receptors and were examined with confocal laser scanning microscopy. GluR1 strong immunoreactivity was confined to Purkinje cell and the molecular layer. Weak GluR1 immunoreactivity was observed surrounding some Golgi cells in the granule cell layer. Intense GluR1 immunoreactivity was localized around Purkinje, basket, and stellate cells. Purkinje cells expressed strong GluR1 immunoreactivity surrounding the cell body,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glutamate receptors; Glia; Neurons; Confocal microscopy.
Ano: 2009 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452009000200001
Imagem não selecionada

Imprime registro no formato completo
Iron and glutathione at the crossroad of redox metabolism in neurons Biol. Res.
ARACENA,PAULA; AGUIRRE,PABLA; MUÑOZ,PABLO; NÚÑEZ,MARCO T.
Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic...
Tipo: Journal article Palavras-chave: Neurons; Iron metabolism; Iron accumulation; Oxidative stress; Glutathione metabolism; Neurodegeneration.
Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017
Imagem não selecionada

Imprime registro no formato completo
Microglia and neurons in the hippocampus of migratory sandpipers BJMBR
Diniz,C.G.; Magalhães,N.G.M.; Sousa,A.A.; Santos Filho,C.; Diniz,D.G.; Lima,C.M.; Oliveira,M.A.; Paulo,D.C.; Pereira,P.D.C.; Sherry,D.F.; Picanço-Diniz,C.W..
The semipalmated sandpiper Calidris pusilla and the spotted sandpiper Actitis macularia are long- and short-distance migrants, respectively. C. pusilla breeds in the sub-arctic and mid-arctic tundra of Canada and Alaska and winters on the north and east coasts of South America. A. macularia breeds in a broad distribution across most of North America from the treeline to the southern United States. It winters in the southern United States, and Central and South America. The autumn migration route of C. pusilla includes a non-stop flight over the Atlantic Ocean, whereas autumn route of A. macularia is largely over land. Because of this difference in their migratory paths and the visuo-spatial recognition tasks involved, we hypothesized that hippocampal...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hippocampus; Neurons; Microglia; Shorebirds; Stereology; Morphometry.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000100603
Imagem não selecionada

Imprime registro no formato completo
Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom International Journal of Morphology
Navarrete Gómez,Patricia; Ormeño,David; Miranda,Antonio; Sánchez Gutiérrez,Raúl; Romero Mejía,Fernando; Parodi Rivera,Jorge.
Since the 1970s, There have been studies of the venom of Latrodectus sp. spiders, in particular the latrotoxin (LTX) of Latrodectus mactans. Many of the studies were aimed at understanding the action of the venom on the muscular system. Now accepted that LTX is able to generate a calcium-permeable membrane pore and modulate the release of synaptic vesicles that activate a receptor and induce cellular changes. Interestingly, when work began with venom obtained from the Latrodectus sp present in Chile, it generated clinical indications similar to the bite of this spider in another country, with some differences in intensity. The purpose of the first studies was to understand the systemic mechanisms of this venom, and other active compounds were studied for...
Tipo: Journal article Palavras-chave: Latrodectus venom; Oocytes; Neurons; Spermatozoa; Contraceptive.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300012
Imagem não selecionada

Imprime registro no formato completo
NEUROTOXIC POTENTIAL OF TRICHLORFON TO MULTIPLE SUBLETHAL DOSES IN WISTAR RATS Acta biol.Colomb.
TAPIERO HERNÁNDEZ,YACSON; RONDÓN BARRAGÁN,IANG; CÉSPEDES RUBIO,ANGEL.
The organophosphates used for pest control induce sensory, motor and psychiatric disturbances after chronic exposure. The ester type is the cause of the intermediate syndrome and delayed neuropathy, in which the white and gray matter in the brain are severely affected.The aim of this study was to evaluate the effect of multiple sublethal doses of Trichlorfon on neurons, astrocytes and myelinated tissue in a rat model of brain neurotoxicity. Trichlorfon (metrifonate) was administered to adult Wistar rats at doses of 11 or 22 μg/kg by oral gavage every seven days for four or eight weeks (four experimental groups) and a control group (placebo). One week after the last dose, animals were euthanized and the brains perfused, removed and cut into coronal...
Tipo: Journal article Palavras-chave: Astrocytes; Myelin; Neurons; Organophosphates; Toxicology.
Ano: 2013 URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2013000300007
Imagem não selecionada

Imprime registro no formato completo
SH Oxidation Stimulates Calcium Release Channels (Ryanodine Receptors) From Excitable Cells Biol. Res.
HIDALGO,CECILIA; BULL,RICARDO; MARENGO,JUAN J; PÉREZ,CLAUDIO F; DONOSO,PAULINA.
The effects of redox reagents on the activity of the intracellular calcium release channels (ryanodine receptors) of skeletal and cardiac muscle, or brain cortex neurons, was examined. In lipid bilayer experiments, oxidizing agents (2,2'-dithiodipyridine or thimerosal) modified the calcium dependence of all single channels studied. After controlled oxidation channels became active at sub &micro;M calcium concentrations and were not inhibited by increasing the calcium concentration to 0.5 mM. Subsequent reduction reversed these effects. Channels purified from amphibian skeletal muscle exhibited the same behavior, indicating that the SH groups responsible for modifying the calcium dependence belong to the channel protein. Parallel experiments that...
Tipo: Journal article Palavras-chave: Calcium dependence; Neurons; Redox state; Ryanodine receptors; Sarcoplasmic reticulum; Skeletal and cardiac muscle.
Ano: 2000 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200011
Imagem não selecionada

Imprime registro no formato completo
Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells Biol. Res.
CARRASCO,MARÍA ANGÉLICA; JAIMOVICH,ENRIQUE; KEMMERLING,ULRIKE; HIDALGO,CECILIA.
Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals. The study of the specific sources of calcium signals involved in regulation of gene expression in skeletal muscle has been addressed only recently. In this tissue, most cytoplasmic and nuclear calcium signals originate from calcium release from internal stores, mediated either by ryanodine receptor (RyR) or IP3 receptor (IP3R) channels. The latter are located both in the sarcoplasmic reticulum (SR) and in the nuclear membrane, and their activation results in long-lasting nuclear calcium increase. The calcium signals mediated by RyR and IP3R are very different in kinetics, amplitude and...
Tipo: Journal article Palavras-chave: Calcium signals; Intracellular stores; Transcription; Oxidation; Neurons; Skeletal muscle.
Ano: 2004 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400028
Registros recuperados: 11
Primeira ... 1 ... Última
 

Empresa Brasileira de Pesquisa Agropecuária - Embrapa
Todos os direitos reservados, conforme Lei n° 9.610
Política de Privacidade
Área restrita

Embrapa
Parque Estação Biológica - PqEB s/n°
Brasília, DF - Brasil - CEP 70770-901
Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco

Valid HTML 4.01 Transitional