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In vitro activity of antimalarials against clinical isolates of Plasmodium falciparum in Yaounde, Cameroon IRD
Ringwald, Pascal; Bickii, J.; Basco, L..
The in vitro activity of nine antimalarials was determined against 119 fresh clinical isolates of #Plasmodium falciparum$ obtained from symptomatic indigenous patients in Yaounde, Cameroun, using the isotopic semimicrotest. Seventy-four parasites were resistant to chloroquine (mean 50% inhibitory concentration [IC50] 337 nM) ; 45 were chloroquine-sensitive (mean IC50 35.6 nM). Twenty-five of 58 chloroquine-resistant parasites were resistant to monodesethylamodiaquine, the biologically active metabolite of amodiaquine. None of the chloroquine-sensitive isolates was resistant to monodesethylamodiaquine (IC50 17.3 nM). Pyronaridine, quinine, mefloquine, halofantrine, and artemether were highly active against the chloroquine-sensitive and the...
Tipo: Text Palavras-chave: PALUDISME; AGENT PATHOGENE; SENSIBILITE RESISTANCE; MEDICAMENT; EFFICACITE; CHLOROQUINE; MONODESETHYLAMODIAQUINE; PYRONARIDINE; QUININE; MEFLOQUINE; HALOFANTRINE; ARTEMETHER; CYCLOGUANIL; PYRIMETHAMINE; SCHEMA THERAPEUTIQUE.
Ano: 1996 URL: http://www.documentation.ird.fr/hor/fdi:010007534
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