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Fungal production of the anti-leukemic enzyme L-asparaginase: from screening to medium development Biological Sciences
Gonçalves, Aline Bacelar; Maia, Ana Carolina Ferreira; Rueda, Jorge Andres; Vanzela, Ana Paula de Figueiredo Conte.
The treatment of acute lymphoblastic leukemia is challenging due to side effects, efficacy of the available drugs, and costs. Utilization of L-asparaginase as a therapeutic agent is essential to increase survival of patients. However, costs are elevated and the bacterial forms of the enzyme cause reactions that result in its inhibition by the immune system. Therapeutics alternatives may be searched among eukaryote producers, like fungi. Twelve strains of filamentous fungi were evaluated regarding expression of L-asparaginase activity. The profile of nitrogen assimilation and radial growth were determined for strains which showed higher production ratios. Three media were formulated after selection of the carbon source and carbon/nitrogen ratio that better...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 2.12.02.02-8 therapeutic enzymes; Filamentous fungi; Acute lymphoblastic leukemia; Penicillium sp.; Fusarium sp. Microbiologia Industrial e de Fermentação.
Ano: 2016 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/32993
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Quantification of mycophenolic acid and citrinin produced by Penicillium sp. using 1H NMR. Repositório Alice
VALENTE, A. M. M. P.; BOFFO, E. F.; MELO, I. S. de; FERREIRA, A. G..
Abstract: This study proposes a simple methodology to construct the production curves of mycophenolic acid by Penicillium sp. (CASP5) and citrinin by Penicillium sp. (CATL1.1) in the crude extract, without any purification. The quantification of the compounds was done by 1H nuclear magnetic resonance (NMR) using the signal integration and an internal standard, N,N-dimethylformamide. Fungi were cultivated for a period of 20 days and quantification of the metabolites in the extracts was done starting from time zero, 2 days and after this period in an interval of 4 days. The maximum production of mycophenolic acid and citrinin was obtained at 12 and 8 days of fermentation, respectively. These results show that the 1H NMR technique was efficient to define the...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Mycophenolic acid; Penicillium sp.; NMR; Fungo; Análise de laboratório; Citrinin; Nuclear magnetic resonance spectroscopy.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1000338
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Volatile effect of essential oils on the growth of pathogens in almonds of Brazil nuts Sci. Agrar.Paran. / SAP
Lorini, Alexandre; Mendes, Bruno Leonardo; Bonaldo, Solange Maria.
Due thea system of extractive harvest of almonds of Brazil nuts is necessary care in the phytosanitary area to maintain postharvest quality of the product. Therefore, we assessed the effect of volatile essential oils of clove (Syzygium aromaticum), cinnamon (Cinnamomum cassia), rosemary (Rosmarinus officinalis) and eucalyptus (Corymbia citriodora) in the development of fungi in almond of Brazil nuts, collected in Itaúba, MT State, Brazil. The design was completely randomized factorial with five treatments in five replicates. We used 100 µL of oils, added on a filter paper on a slide glass in the center of Petri dishes with five almonds around. The plates were sealed and kept at 25 ± 2 °C/dark. Two evaluations (five and ten days after incubation) of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aspergillus sp.; Bertholletia excelsa; Controle alternativo; Penicillium sp.; Rhizopus sp..
Ano: 2016 URL: http://e-revista.unioeste.br/index.php/scientiaagraria/article/view/10792
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