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Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities. Repositório Alice
SANTOS, R. de C. dos; BONAMINA, F.; PÉRICO, L. L.; RODRIGUES, V. P.; ZANATTA, A. C.; RODRIGUES, C. M.; SANNOMIYA, M.; RAMOS. M. A. dos S.; BONIFÁCIO, B. V.; BAUAB, T. M.; TAMASHIRO, J.; ROCHA, L. R. M. da; VILEGAS, W.; HIRUMA-LIMA, C. A..
Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Healing effect; Peptic ulcer; Anti-inflammatory activity.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1107125
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Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment BABT
Patel,Dhaval J; Patel,Jayvadan K.
The present study was performed to design and evaluate the famotidine loaded mucoadhesive nanosuspension for aspirin induced ulcer. A 3-factor, 3-level Box-Behnken design was applied to study the effects of amount of the beads (X1), PVPK-30(X2) and Tween-80 (X3) on the particle size (Y1), and cumulative percentage drug released after 1h (Y2). The optimization was performed using the desirability function and contour plots. The scanning electron microscopy (SEM) showed the nanoparticles as spherical in shape. The differential scanning calorimetry (DSC) analysis indicated that there was substantial crystallinity change in the nanoparticle compared with the pure drug. Ex-vivo mucoadhesion study showed that famotidine mucoadhesive nanoparticles possessed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Famotidine; Nanosuspension; Box-Behnken design; Mucoadhesion; Peptic ulcer.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000200007
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Effect of Helicobacter pylori infection and acid blockade by lansoprazole on clarithromycin bioavailability BJMBR
Ortiz,R.A.M.; Calafatti,S.A.; Moraes,L.A.; Deguer,M.; Ecclissato,C.C.; Marchioretto,M.A.M.; Ribeiro,M.L.; Bernasconi,G.; Pedrazzoli Jr,J..
The effect of proton pump inhibitors and Helicobacter pylori infection on the bioavailability of antibiotics is poorly understood. We determined the effects of 5-day oral administration of 60 mg lansoprazole on the bioavailability of clarithromycin in individuals with and without H. pylori infection. Thirteen H. pylori-infected and 10 non-infected healthy volunteers were enrolled in a study with an open-randomized two-period crossover design and a 21-day washout period between phases. Plasma concentrations of clarithromycin in subjects with and without lansoprazole pre-treatment were measured by liquid chromatography coupled to a tandem mass spectrometer. Clarithromycin Cmax and AUC0-10 h were significantly reduced after lansoprazole administration. In...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Clarithromycin; Helicobacter pylori; Lansoprazole; Peptic ulcer; Pharmacokinetics.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300014
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Fate of Helicobacter pylori artificially inoculated in lettuce and carrot samples BJM
Gomes,Bruna C.; Martinis,Elaine C.P. de.
Helicobacter pylori is known, worldwide, as the causative agent of gastric diseases. However, its transmission route has not been completely understood. To evaluate the survival of H. pylori (a clinical and a reference strain) artificially inoculated on lettuce and carrot samples, portions of 25 g were inoculated with approximately 10(6) CFU/g of H. pylori and packed under normal and/or modified atmosphere (3% oxygen, 10% carbon dioxide, and 87% nitrogen). The inoculated food samples were stored at 8ºC, with daily enumeration of H. pylori populations on Columbia blood agar (CBA) and/ or Helicobacter pylori Special Peptone Agar (HPSPA). When CBA with antibiotics was used, the clinical isolate H. pylori HP1 was detected for up to 72 h in sanitized lettuce...
Tipo: Info:eu-repo/semantics/article Palavras-chave: H. pylori; Peptic ulcer; Modified atmosphere; Vegetable.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100024
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Investigation of the association between clinical outcome and the cag pathogenicity-island and other virulence genes of Helicobacter pylori isolates from patients with dyspepsia in Eastern Turkey BJM
Ozbey,Gokben; Demirel,Ulvi; Aygun,Cem; Ertas,Hasan Basri.
The aims of our work were to determine the presence of the cag pathogenicity-island (cag PAI) and other virulence genes of Helicobacter pylori recovered from patients with gastritis and peptic ulcer, and to investigate the correlation of these virulence genes with clinical outcome. The presence of the cagA, the promoter regions of cagA, cagE, cagT, and the left end of cag-PAI (LEC), cag right junction (cagRJ), the plasticity region open reading frames (ORFs), vacA and oipA genes among 69 H. pylori isolates were determined by polymerase chain reaction. Intact cag PAI was detected in only one (1.4%) isolate. The cagA gene was identified in 52.1% and 76.2% of isolates from patients with dyspepsia (gastritis and peptic ulcer), respectively. The plasticity...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Helicobacter pylori; Gastritis; Peptic ulcer; Cag pathogenicity-island; Polymerase chain reaction.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000400034
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Primary gastric fundus tuberculosis in immunocompetent patient: a case report and literature review BJID
Khan,Fahmi Yousef; AlAni,Ahmed; Al-Rikabi,Ammar; Mizrakhshi,A.; Osman,Mohamed El-Mudathir.
We report on a 29-year-old Pakistani man who presented to the clinic with epigastric pain, of one-month duration. He did not report fever, cough, vomiting blood, passing black stools, loss of appetite or diarrhea. However, he had lost 7 kg since his symptoms had begun. Clinical examination was unremarkable. Laboratory results were within normal limits. An abdominal CT scan showed a mass with enhancement in the stomach. Gastric endoscopy revealed an ulcerative mass in the fundus. An endoscopic-biopsy specimen revealed caseating granulomas with acid-fast bacilli. The patient was diagnosed to have primary gastric tuberculosis, and antituberculous medications were initiated. Cultures of the gastric mass subsequently grew Mycobacterium tuberculosis sensitive to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gastric tuberculosis; Hematemesis; Peptic ulcer; Stomach perforation.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500020
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To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori BJID
Hajiaghamohammadi,Ali Akbar; Zargar,Ali; Oveisi,Sonia; Samimi,Rasoul; Reisian,Sedigheh.
ABSTRACT Objective: The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen. Methods: In this randomized controlled clinical trial, 120 patients who had positive rapid urease test were included and assigned to two treatment groups: control group that received a clarithromycin-based triple regimen, and study group that received licorice in addition to the clarithromycin-based regimen for two weeks. H. pylori eradication was assessed six weeks after therapy. Data was analyzed by chi-square and t-test with SPSS 16 software. Results: Mean ages and SD were 38.8...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Helicobacter pylori; Licorice; Dyspepsia; Peptic ulcer.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600534
Registros recuperados: 7
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