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Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis Biol. Res.
WRIGHT,MARCIA M.; MCMASTER,CHRISTOPHER R..
Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous. Paradoxically, many cancer chemotherapeutics preferentially kill cancer cells by inducing apoptosis. Diacylglycerol is a lipid second messenger that regulates cell growth and apoptosis and is produced during signal transduction by hydrolysis of membrane phospholipids. Protein kinase Cs are a family of diacylglycerol responsive enzymes that are recruited to cellular membranes as a consequence of diacylglycerol production where they phosphorylate specific target proteins responsible for regulating cell growth. In this review, we will first summarize our current understanding...
Tipo: Journal article Palavras-chave: Apoptosis; Diacylglycerol; Farnesol; Phorbol ester; Protein kinase C.
Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200014
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The Effect of Jatropha Curcas Seed Meal on Growth Performance and Internal Organs Development and Lesions in Broiler Chickens Rev. Bras. Ciênc. Avic.
Barros,CR; Rodrigues,MAM; Nunes,FM; Kasuya,MCM; Luz,JMR da; Alves,A; Ferreira,LMM; Pinheiro,V; Mourão,JL.
ABSTRACT The meal of Jatropha curcas (JCM) seed is a by-product of the biofuel industry and may potentially to be used as animal feed. However, its toxicity has prevented its utilization in animal nutrition mainly due to its high concentration of phorbol esters. This study was conducted to evaluate the effects of the dietary inclusion of JCM on the growth performance, feed digestibility and internal organs development of broilers. Thirty two 48-d-old Ross 308 broiler chickens housed in 16 pens (2 birds/pen) were used in this study. Birds were randomly allocated to dietary treatments comprising four JCM levels (negative control, 25, 50, or 100 g JCM/kg of diet) for four weeks. Results showed that increasing levels of JCM had a negative impact on broiler...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Broiler; Jatropha curcas; Phorbol ester; Toxicity.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2015001000001
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