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Registros recuperados: 5
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A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor γ2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls International Journal of Morphology
Guzmán,Neftalí; Erices,Leonardo; Valdés,Patricio; Salazar,Luis A.
The 34C>G (Prol2Ala) polymorphic variant of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene has been associated with polycystic ovary syndrome (PCOS). However, the results between populations are contradictory. Thus, in the present study was investigated the possible association between 34C>G polymorphism at the PPAR-γ2 gene and PCOS in Chilean women. A total of 50 unrelated women (29.1 + 8.1 years) with diagnosis of PCOS and 75 healthy controls (29.3+ 9.3 years) were included in this study. Serum lipids, glucose and uric acid levels were determined by enzymatic-colorimetric methods. The 34C>G variant in the PPAR-γ2 gene was analyzed by PCR-RFLP. Women with PCOS exhibited a higher levels of...
Tipo: Journal article Palavras-chave: Polycystic ovary syndrome; Peroxime proliferator-activated receptor; Prol2Ala polymorphism.
Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400030
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Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome BJMBR
Prata Lima,M.F.; Baracat,E.C.; Simões,M.J..
The current study was conducted to investigate the relationship between melatonin and chronic anovulation. Adult (3-4 months old) female Wistar rats were submitted to pinealectomy: group I: pinealectomized ovariectomized melatonin-treated (N = 10); group II: pinealectomized ovariectomized placebo-treated (N = 12); group III: pinealectomized light-treated placebo-treated(N = 10) or maintained under continuous light; group IV: maintained under continuous light, ovariectomized melatonin-treated (N = 22); group V: maintained under continuous light, ovariectomized placebo-treated (N = 10); group VI: maintained under continuous light placebo-treated (N = 10). In order to assess ovarian modifications, unilateral ovariectomy was performed during the fourth month...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Melatonin; Polycystic ovary syndrome; Pineal body; Anovulation.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000700007
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Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome BJMBR
Meenakumari,K.J.; Agarwal,S.; Krishna,A.; Pandey,L.K..
The causes of luteal phase progesterone deficiency in polycystic ovary syndrome (PCOS) are not known. To determine the possible involvement of hyperinsulinemia in luteal phase progesterone deficiency in women with PCOS, we examined the relationship between progesterone, luteinizing hormone (LH) and insulin during the luteal phase and studied the effect of metformin on luteal progesterone levels in PCOS. Patients with PCOS (19 women aged 18-35 years) were treated with metformin (500 mg three times daily) for 4 weeks prior to the test cycle and throughout the study period, and submitted to ovulation induction with clomiphene citrate. Blood samples were collected from control (N = 5, same age range as PCOS women) and PCOS women during the late follicular (one...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Polycystic ovary syndrome; Metformin; Luteal phase defect; Progesterone.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001100007
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Positive correlation of serum leptin with estradiol levels in patients with polycystic ovary syndrome BJMBR
Mendonça,H.C.; Montenegro Junior,R.M.; Foss,M.C.; Silva de Sá,M.F.; Ferriani,R.A..
Patients with polycystic ovary syndrome (PCOS) usually are obese, insulin resistant and hyperinsulinemic. The known association between leptin, obesity andinsulin action suggests that leptin may have a role in PCOS but this has only been addressed peripherally. This study was designed to assess the relationship between serum leptin and the anthropometric, metabolic and endocrine variables of obese (body mass index, BMI ³30 kg/m²) and non-obese (BMI <30 kg/m²) PCOS patients. Twenty-eight PCOS patients and 24 control women subdivided into obese and non-obese groups were evaluated. Leptin, androgens, lipids, gonadotrophins and insulin-glucose response to the oral glucose tolerance test were measured by radioimmunoassay in all participants. The assays were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Leptin; Polycystic ovary syndrome; Insulin; Insulin sensitivity; Estrogen.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500015
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The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals BJMBR
Oliveira,I.O.; Lhullier,C.; Brum,I.S.; Spritzer,P.M..
The aim of the present study was to determine the expression of the genes for type 1 (SDR5A1) and type 2 (SDR5A2) 5alpha-reductase isoenzymes in scalp hairs plucked from 33 hirsute patients (20 with polycystic ovary syndrome and 13 with idiopathic hirsutism) and compare it with that of 10 men and 15 normal women. SDR5A1 and SDR5A2 expression was estimated by RT-PCR using the gene of the ubiquitously expressed protein ß2-microglobulin as an internal control. The results are expressed as arbitrary units in relation to ß2-microglobulin absorbance (mean ± SEM). SDR5A2 expression was not detected in any hair samples analyzed in this study. No differences were found in SDR5A1 mRNA levels between men and normal women (0.78 ± 0.05 vs 0.74 ± 0.06, respectively)....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hair follicle; Hirsutism; 5alpha-Reductase; Polycystic ovary syndrome.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000024
Registros recuperados: 5
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