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Registros recuperados: 35
Primeira ... 12 ... Última
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A FRET analysis to unravel the role of cholesterol in Rac1 and PI 3-kinase activation in the InlB/Met signalling pathway Inra
Seveau, S.; Tham, T. N.; Payrastre, B.; Hoppe, A. D.; Swanson, J. A.; Cossart, P..
The signalling pathway for the hepatocyte growth factor receptor, Met/HGF-R, is hijacked by the bacterial surface protein InlB to induce Listeria monocytogenes entry into non-phagocytic cells. We previously showed that Listeria invades host cells by interacting with specialized microdomains of the host plasma membrane called lipid rafts. In this study, we analysed in living cells signalling events that are crucial for Listeria entry using a fluorescence resonance energy transfer-based microscopic method. Phosphoinositide (PI) 3-kinase activity and Rac1 signalling induced by Listeria interacting with epithelial cells were monitored as well as signalling induced by soluble InlB and the Met natural ligand HGF. We found that InlB and HGF induced...
Tipo: Journal Article Palavras-chave: PROTEINE MICROBIENNE; LISTERIA MONOCYTOGENES; BACTERIE PATHOGENE; MALADIE INFECTIEUSE; CELLULE EPITHELIALE; INTERNALINE InlB; RECEPTEUR; FACTEUR DE CROISSANCE; SIGNAL; ENZYME; CHOLESTEROL; PHOSPHOINOSITIDE KINASE.
Ano: 2007 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD200993335bc&uri=/notices/prodinra1/2009/09/
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A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation Inra
Kara, E.; Crépieux, P.; Gauthier, C.; Martinat, N.; Piketty, V.; Guillou, F.; Reiter, E..
Tipo: Journal Article Palavras-chave: PROTEINE KINASE; RECEPTEUR; ARRESTINE FSH.
Ano: 2006 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2007f52c5a65&uri=/notices/prodinra1/2008/01/
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Activation of STAT factors by prolactin, interferon-gamma, growth hormones, and a tyrosine phosphatase inhibitor in rabbit primary mammary epithelial cells Inra
Tourkine, N.; Schindler, C.; Larose, M.; Houdebine, L.M..
Tipo: Journal Article Palavras-chave: HORMONE DE CROISSANCE; CELLULE EPITHELIALE; TYROSINE KINASE; TYROSINE PHOSPHATASE; FACTEUR CYTOPLASMIQUE; PROLACTINE; RECEPTEUR.
Ano: 1995 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB9600002893057370&uri=/notices/prodinra1/2010/09/
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Antidiarrhoeal properties of a novel sigma ligand (JO2871) on toxigenic diarrhoea in mice: mechanisms of action Inra
Théodorou, V.; Chovet, M.; Eutamène, H.; Fargeau, H.; Dassaud, M.; Toulouse, M.; Bihoreau, C.; Roman, F.J.; Buéno, L..
Tipo: Journal Article Palavras-chave: EFFECT ANTI-DIARRHEE; INFECTION INTESTINALE; JO 2871; INTESTIN GRELE; LIGAND; RECEPTEUR; MODELE ANIMAL; SALMONELLA ENTERIDITIS.
Ano: 2002 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB0500023823109866&uri=/notices/prodinra1/2009/11/
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BMPs and BMPRs in chicken ovary and effects of BMP-4 and -7 on granulosa cell proliferation and progesterone production in vitro Inra
Onagbesan, O.M.; Bruggeman, V.; van As, P.; Tona, K.; Williams, J.; Decuypere, E..
Tipo: Journal Article Palavras-chave: RECEPTEUR; REPRODUCTION FEMELLE; PROGESTERONE; CROISSANCE CELLULAIRE; CELLULE DE LA GRANULOSA.
Ano: 2003 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB0400020699106419&uri=/notices/prodinra1/2010/09/
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Calcium activates a chloride conductance likely involved in olfactory receptor neuron repolarization in the moth Spodoptera littoralis Inra
Pézier, A.; Grauso, M.; Acquistapace, A.; Monsempes, C.; Rospars, J.P.; Lucas, P..
The response of insect olfactory receptor neurons (ORNs) to odorants involves the opening of Ca2+-permeable channels, generating an increase in intracellular Ca2+ concentration. Here, we studied the downstream effect of this Ca2+ rise in cultured ORNs of the moth Spodoptera littoralis. Intracellular dialysis of Ca2+ from the patch pipette in whole-cell patch-clamp configuration activated a conductance with a K-1/2 of 2.8 mu M. Intracellular and extracellular anionic and cationic substitutions demonstrated that Cl- carries this current. The anion permeability sequence I- > NO3- > Br- > Cl- > CH3SO(3)(-) >> gluconate(-) of the Ca2+-activated Cl- channel suggests a weak electrical field pore of the channel. The Ca2+-activated current partly...
Tipo: Journal Article Palavras-chave: CALCIUM; OLFACTION; NEURONE; RECEPTEUR; MITE; SPODOPTERA LITTORALIS; LEPIDOPTERA; INSECTE; CANAL A CALCIUM; CHLORURE; PERMEABILITE; CONCENTRATION; TENEUR EN CALCIUM NUCLEOTIDE-GATED CHANNELS; SMOOTH-MUSCLE-CELLS; PROTEIN-KINASE-C; ANTENNAL NEURONS; SENSORY NEURONS; IN-VITRO; CURRENTS; TRANSDUCTION; VOLUME; CILIA.
Ano: 2010 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2010398ba406&uri=/notices/prodinra1/2010/10/
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Cloning and expression pattern of a putative octopamine/tyramine receptor in antennae of the noctuid moth Mamestra brassicae Inra
Brigaud, I.; Grosmaître, X.; Francois, M.C.; Jacquin-Joly, E..
In insects, biogenic amines have been shown to play an important role in olfactory plasticity. In a first attempt to decipher the underlying molecular mechanisms, we report the molecular cloning and precise expression pattern of a newly identified octopamine/tyramine-receptor-encoding gene in the antennae of the noctuid moth Mamestra brassicae (MbraOAR/TAR). A full-length cDNA has been obtained through homology cloning in combination with rapid amplification of cDNA ends/polymerase chain reaction; the deduced protein exhibits high identities with previously identified octopamine/tyramine receptors in other moths. In situ hybridization within the antennae has revealed that MbraOAR/TAR is expressed at the bases of both pheromone-sensitive and non-sensitive...
Tipo: Journal Article Palavras-chave: CLONAGE; LOBE ANTENNAIRE; NOCTUIDAE; MITE; HEXAPODA; ARTHROPODA; AMINE BIOGENIQUE; RECEPTEUR; CLONAGE MOLECULAIRE; ADNC; POLYMORPHISME; PCR; PHEROMONE; LEPIDOPTERA; MAMESTRA BRASSICAE OCTOPAMINE/TYRAMINE RECEPTOR; EXPRESSION PATTERN; OLFACTION; OLFACTORY PLASTICITY.
Ano: 2009 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD201084fc8d7c&uri=/notices/prodinra1/2010/11/
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Cloning of an octopamine/tyramine receptor and plasticity of its expression as a function of adult sexual maturation in the male moth Agrotis ipsilon Inra
Duportets, L.; Barrozo, R.B.; Bozzolan, F.; Gaertner, C.; Anton, S.; Gadenne, C.; Debernard, S..
In the male moth Agrotis ipsilon behavioural response and antennal lobe (AL) neuron sensitivity to the female-produced sex pheromone increase with age and juvenile hormone (JH) level. We recently showed that the neuromodulator, octopamine (OA), interacts with JH in this age-dependent olfactory plasticity. To further elucidate its role, we cloned a full cDNA encoding a protein that presents biochemical features essential to OA/tyramine receptor (AipsOAR/TAR) function. The AipsOAR/TAR transcript was detected predominantly in the antennae, the brain and, more specifically, in ALs where its expression level varied concomitantly with age. This expression plasticity indicates that AipsOAR/TAR might be involved in central processing of the pheromone signal during...
Tipo: Journal Article Palavras-chave: LOBE ANTENNAIRE; LEPIDOPTERA; NOCTUIDAE; AGROPIS IPSILON; RECEPTEUR; OLFACTION; MITE; INSECTE; MATURATION SEXUELLE; ARTHROPODA; HEXAPODA; NEURONE; PHEROMONE; HORMONE; ADNC; CLONAGE; COMPORTEMENT SEXUEL; ATTRACTIF SEXUEL ANTENNAL LOBE; OCTOPAMINE/TYRAMINE RECEPTOR; OLFACTORY PROCESSING; MATURATION; EXPRESSION PLASTICITY.
Ano: 2010 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20102d18e75d&uri=/notices/prodinra1/2011/02/
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Competitive and noncompetitive odorant interactions in the early neural coding of odorant mixtures Inra
Rospars, J.P.; Lansky, P.; Chaput, M.; Duchamp-Viret, P..
Most olfactory receptor neurons (ORNs) express a single type of olfactory receptor that is differentially sensitive to a wide variety of odorant molecules. The diversity of possible odorant-receptor interactions raises challenging problems for the coding of complex mixtures of many odorants, which make up the vast majority of real world odors. Pure competition, the simplest kind of interaction, arises when two or more agonists can bind to the main receptor site, which triggers receptor activation, although only one can be bound at a time. Noncompetitive effects may result from various mechanisms, including agonist binding to another site, which modifies the receptor properties at the main binding site. Here, we investigated the electrophysiological...
Tipo: Journal Article Palavras-chave: CODAGE; MODELE; OLFACTION; NEURONE; RECEPTEUR; ODEUR; INTERACTION MOLECULAIRE; CONCENTRATION; ANALYSE STATISTIQUE  SENSORY CODING; OLFACTORY RECEPTOR NEURON; IN VIVO; SIGNAL TRANSDUCTION; ALLOSTERY; MIXTURE INTERACTION.
Ano: 2008 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20105031bac0&uri=/notices/prodinra1/2010/10/
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Computational model of the insect pheromone transduction cascade Inra
Gu, Y.; Lucas, P.; Rospars, J.P..
All sensory neurons transduce their natural stimulus, whether a molecule, a photon, or a mechanical force, in an electrical current flowing through their sensory membrane via similar molecular and ionic mechanisms. Olfactory receptor neurons (ORNs), whose stimuli are volatile molecules, are no exception, including one of the best known: the exquisitely sensitive ORNs of male moths that detect the sexual pheromone released by conspecific females. We provide a detailed computational model of the intracellular molecular mechanisms at work in this ORN type. We describe qualitatively and quantitatively how the initial event, the interaction of pheromone molecules with specialized receptors at the ORN surface, is amplified through a sequence of linked...
Tipo: Journal Article Palavras-chave: MODELE; INSECTE; PHEROMONE; NEURONE; RECEPTEUR; MITE; PROTEINE; ACTIVITE ENZYMATIQUE; CANAL A CALCIUM; CANAL A POTASSIUM; PROTEINE KINASE C; CALMODULINE; OLFACTION OLFACTORY RECEPTOR NEURONS; PROTEIN-KINASE-C; DROSOPHILA ODORANT RECEPTORS; ANTHERAEA-POLYPHEMUS; CHLORIDE CURRENT; PHOSPHOLIPASE-C; BOMBYX-MORI; SENSILLA TRICHODEA; DEGRADING ENZYME; CATION CHANNELS.
Ano: 2009 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2010634023e&uri=/notices/prodinra1/2010/10/
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Effects of cold-exposure and subsequent recovery on cellular proliferation with influence of 20-hydroxyecdysone in a lepidopteran cell line (IAL-PID2) Inra
Lalouette, L.; Renault, D.; Ravaux, J.; Siaussat, D..
In developing insects, the peak level of 20-hydroxyecdysone (20E) initiates a decrease in cyclin expression, which subsequently triggers an arrest of cellular proliferation and the start of differentiation, finally culminating in the moult. We investigated the impact of cold-exposure (4 degrees C) and recovery (26 degrees C) on the cell cycle activity of the Plodia interpunctella Lepidoptera cell line IAL-PID2 and on the expression of B-type cyclin (PcycB), ecdysone receptor (B1-isoform; PiEcR-B1), and Hsc70 (PiHsc70) mRNA. Cold-exposure significantly reduced expression of these mRNAs, while their levels increased to above control values during subsequent recovery at the normal growth temperature. When cold-exposed cells were returned to 26 degrees C, cell...
Tipo: Journal Article Palavras-chave: FROID; DEVELOPPEMENT CELLULAIRE; EFFET DE LA TEMPERATURE; LEPIDOPTERA; RECEPTEUR; EXPRESSION DES GENES; ARN MESSAGER; PROTEINE; HORMONE STEROIDE; PLODIA INTERPUNCTELLA; CARTOGRAPHIE; ELECTROPHORESE; MITE; PYRALIDAE PROLIFERATION; 20-HYDROXYECDYSONE; IAL-PID2 CELLS; STEROID HORMONE RECEPTOR SUPERFAMILY; HEAT SHOCK PROTEINS 70; COLD SHOCK.
Ano: 2010 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2010eed35965&uri=/notices/prodinra1/2010/09/
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Efficient olfactory coding in the pheromone receptor neuron of a moth Inra
Kostal, L.; Lansky, P.; Rospars, J.P..
Efficient coding is an overarching principle, well tested in visual and auditory neurobiology, which states that sensory neurons are adapted to the statistical characteristics of their natural stimulus - in brief, neurons best process those stimuli that occur most frequently. To assess its validity in olfaction, we examine the pheromone communication of moths, in which males locate their female mates by the pheromone they release. We determine the characteristics of the pheromone plume which are best detected by the male reception system. We show that they are in agreement with plume measurements in the field, so providing quantitative evidence that this system also obeys the efficient coding principle. Exploring the quantitative relationship between the...
Tipo: Journal Article Palavras-chave: ANTHERAEA POLYPHEMUS; INSECTE; LEPIDOPTERA; ANALYSE STATISTIQUE; CHEMORECEPTEUR; MODELE CINETIQUE; MITE; OLFACTION; PHEROMONE; NEURONE; RECEPTEUR; STIMULATION; COMMUNICATION; MODELISATION; PROBABILITE ORIENTAL FRUIT MOTH; ANTHERAEA-POLYPHEMUS; KINETIC-MODEL; INFORMATION; STIMULATION; PLUMES; CELLS; CHEMORECEPTORS; FLUCTUATIONS; ACTIVATION.
Ano: 2008 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2010f45c7b7b&uri=/notices/prodinra1/2010/10/
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Follicle-stimulating hormone (FSH) activates extracellular signal-regulated kinase phosphorylation independently of beta-arrestin- and dynamin-mediated FSH receptor internalization Inra
Piketty, V.; Kara, E.; Guillou, F.; Reiter, E.; Crepieux, P..
Tipo: Journal Article Palavras-chave: RECEPTEUR; ARRESTINE; PROTEINE KINASE; SIGNAL EXTRA-CELLULAIRE FSH.
Ano: 2006 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD200712c4e552&uri=/notices/prodinra1/2008/01/
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G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells Inra
Marion, S.; Kara, E.; Crepieux, P.; Piketty, V.; Martinat, N.; Guillou, F.; Reiter, E..
Tipo: Journal Article Palavras-chave: CELLULE DE SERTOLI; FSH; RECEPTEUR; ARRESTINE; PROTEINE KINASE; PROTEINE G.
Ano: 2006 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD200715f36fec&uri=/notices/prodinra1/2008/01/
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Hedonic taste in Drosophila revealed by olfactory receptors expressed in taste neurons Inra
Hiroi, M.; Tanimura, T.; Marion-Poll, F..
Taste and olfaction are each tuned to a unique set of chemicals in the outside world, and their corresponding sensory spaces are mapped in different areas in the brain. This dichotomy matches categories of receptors detecting molecules either in the gaseous or in the liquid phase in terrestrial animals. However, in Drosophila olfactory and gustatory neurons express receptors which belong to the same family of 7-transmembrane domain proteins. Striking overlaps exist in their sequence structure and in their expression pattern, suggesting that there might be some functional commonalities between them. In this work, we tested the assumption that Drosophila olfactory receptor proteins are compatible with taste neurons by ectopically expressing an olfactory...
Tipo: Journal Article Palavras-chave: NEURONE; RECEPTEUR; PROTEINE; SENSATION; GOUT; FONCTION PHYSIOLOGIQUE; INSECTE; ARTHROPODA; HEXAPODA; STIMULUS; SUCRE; CAFEINE  OLFACTION; NEURON; PROTEIN RECEPTOR; TASTE; DROSOPHILA.
Ano: 2008 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD201058c69fd&uri=/notices/prodinra1/2010/10/
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Identification of a functional androgen response element in the promoter of the gene for the androgen-regulated aldose reductase-like protein specific to the mouse vas deferens Inra
Fabre, S.; Manin, M.; Pailhoux, E.; Veyssière, G.; Jean, C..
Tipo: Journal Article Palavras-chave: REGULATION DE LA TRANSCRIPTION; ANDROGENE; RECEPTEUR.
Ano: 1994 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB9600008051058022&uri=/notices/prodinra1/2010/09/
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In vivo involvement of cytochrome P450 4A family in the oxidative metabolism of the lipid peroxidation product trans-4-hydroxy-2-nonenal, using PPARalpha-deficient mice Inra
Guéraud, F.; Alary, J.; Costet, P.; Debrauwer, L.; Dolo, L.; Pineau, T.; Paris, A..
Tipo: Journal Article Palavras-chave: CYTOCHROME P450; PEROXYDATION; TRANSHYDROXYNONENAL; HYDROXYLATION; SPECTROMETRIE DE MASSE; TECHNIQUE ANALYTIQUE; ACIDE HYDROXYNONENOIQUE; CHROMATOGRAPHIE HPLC; RECEPTEUR.
Ano: 1999 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB0300006749096300&uri=/notices/prodinra1/2010/09/
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Insulin-induced activation of a phosphatidyl inositol 3-kinase. Demonstration that the P85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells Inra
Levy-Toledano, R.; Taouis, M.; Blaettler, D.; Gorden, P.; Taylor, S.I..
Tipo: Journal Article Palavras-chave: INSULINE; HORMONE PANCREATIQUE; RECEPTEUR; IMMUNORESISTANCE.
Ano: 1994 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB9500020403049616&uri=/notices/prodinra1/2010/09/
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Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs Inra
Gay, J.; Fioramonti, J.; Garcia-Villar, R.; Emonds-Alt, X; Buéno, L..
Tipo: Journal Article Palavras-chave: TACHYKININE; RECEPTEUR; AFRIQUE OCCIDENTALE; ALLERGIE ALIMENTAIRE; BETA LACTOGLOBULINE; ANTAGONISTE; TEST ELISA; MASTOCYTE; IMMUNOGLOBULINE.
Ano: 1999 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB0300013041096496&uri=/notices/prodinra1/2009/11/
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Listeria InlB takes a different route to met Inra
Veiga, E.; Cossart, P..
InlB, a surface protein of the human bacterial pathogen Listeria monocytogenes, interacts with the receptor tyrosine kinase Met on host cells to enable bacterial invasion. In this issue, Niemann et al. (2007) provide the first structural evidence that InlB does not compete for the same interaction site on Met as the natural ligand HGF.
Tipo: Journal Article Palavras-chave: BACTERIE PATHOGENE; LISTERIA MONOCYTOGENES; PROTEINE; RECEPTEUR; TYROSINE KINASE; HOMME; SURFACE CELLULAIRE.
Ano: 2007 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2009a8e51aff&uri=/notices/prodinra1/2009/09/
Registros recuperados: 35
Primeira ... 12 ... Última
 

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