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Rescuing axons from degeneration does not affect retinal ganglion cell death BJMBR
de Lima,S.; Mietto,B.S.; Paula,C.; Muniz,T.; Martinez,A.M.B.; Gardino,P.F..
After a traumatic injury to the central nervous system, the distal stumps of axons undergo Wallerian degeneration (WD), an event that comprises cytoskeleton and myelin breakdown, astrocytic gliosis, and overexpression of proteins that inhibit axonal regrowth. By contrast, injured neuronal cell bodies show features characteristic of attempts to initiate the regenerative process of elongating their axons. The main molecular event that leads to WD is an increase in the intracellular calcium concentration, which activates calpains, calcium-dependent proteases that degrade cytoskeleton proteins. The aim of our study was to investigate whether preventing axonal degeneration would impact the survival of retinal ganglion cells (RGCs) after crushing the optic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Optic nerve crush; Calpain inhibitor; Axon preservation; Axon degeneration; Retinal ganglion cells; Cell survival.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400705
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Veratridine increases the survival of retinal ganglion cells in vitro BJMBR
Pereira,S.P.F.; Araujo,E.G..
Neuronal cell death is an important phenomenon involving many biochemical pathways. This degenerative event has been studied to understand how the cells activate the mechanisms that lead to self-destruction. Target cells and afferent cells play a relevant role in the regulation of natural cell death. We studied the effect of veratridine (1.5, 3.0, 4.5 and 6.0 µM) on the survival of neonatal rat retinal ganglion cells in vitro. Veratridine (3.0 µM), a well-known depolarizing agent that opens the Na+ channel, promoted a two-fold increase in the survival of retinal ganglion cells kept in culture for 48 h. This effect was dose-dependent and was blocked by 1.0 µM tetrodotoxin (a classical voltage-dependent Na+ channel blocker) and 30.0 µM flunarizine (a Na+ and...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Veratridine; Retinal ganglion cells; Natural cell death; Development; Retina.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200014
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