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Antitumor compounds from Streptomyces sp. KML-2, isolated from Khewra salt mines, Pakistan Biol. Res.
Aftab,Usman; Zechel,David L.; Sajid,Imran.
BACKGROUND: Actinomycetes are gram positive bacteria with high G + C content in their DNA and are capable of producing variety of secondary metabolites. Many of these metabolites possess different biological activities and have the potential to be developed as therapeutic agents. The aim of the present study was to screen actinomycetes inhabiting halophilic environment such as Khewra salt mines present in Pakistan for cytotoxic and antitumor compounds RESULTS: An actiomycetes strain designated as Streptomyces sp. KML-2 was isolated from a saline soil of Khewra salt mines, Pakistan. The strain Streptomyces sp. KML-2 showed 84 % cytotoxic activity against larvae of Artemiasalina. In the screening phase, the strain exhibited significant antitumor activity...
Tipo: Journal article Palavras-chave: Streptomyces sp KML-2 Antitumor activity Chromomycin SA 1-(1 H-indol-3-yl)-propane-1; 2; 3-triol.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100058
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