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Registros recuperados: 26
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Antiangiogenic effect of betamethasone on the chick cam stimulated by TA3 tumor supernatant Biol. Res.
LEMUS,DAVID; DABANCENS,ALFREDO; ILLANES,JULIO; FUENZALIDA,MARCELA; GUERRERO,ANIBAL; LÓPEZ,CLAUDIA.
Tumor growth is the result of combined cell proliferation overwhelming cell death and neoangiogenesis. This report shows CAM angiogenesis promoted by TA3 tumor supernatant with or without low dosis of betamethasone (Minimal antiangiogenic concentration: ß-MAAC). Methylcellulose discs instilled with 10 µl of ß-MAAC (0.08 µg/ml),10 µl of tumor supernatant(TA3ts),5 µl ß-MAAC + 5 µl TA3ts, and 10 µl of PBS as control were implanted in host chick eggs. On day 12, the grafts were removed, photographed and fixed. Sections were stained in parallel, one and three with hematoxylin-eosin, and section two by the Tunel method. The number of vessels was evaluated in a microscopic field of the CAM (2250 µm2 ). The results show that ß-MAAC produced a significant...
Tipo: Journal article Palavras-chave: Antiangiogenesis; Betamethasone; CAM; Tumor.
Ano: 2001 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300010
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Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumexhastatus D. Don Biol. Res.
Ahmad,Sajjad; Ullah,Farhat; Ayaz,Muhammad; Zeb,Anwar; Ullah,Farman; Sadiq,Abdul.
BACKGROUND: Cancer, being the foremost challenge of the modern era and the focus of world-class investigators, gargantuan research is in progress worldwide to explore novel therapeutic for its management. The exploitation of natural sources has been proven to be an excellent approach to treat or minify the excessive angiogenesis and proliferation of cells. Similarly, based the ethnomedicinal uses and literature survey, the current study is designed to explore the anti-tumor and anti-angiogenic potentials of Rumex hastatus. Anti-tumor and anti-angiogenic activities were carried out using potato-disc model and chorioallantoic membrane (CAM) assay respectively. Moreover, R. hastatus was also assessed for antibacterial activity against Agrobacterium...
Tipo: Journal article Palavras-chave: Rumex hastatus; Agrobacterium tumefaciens; Saponins; Angiogenesis; Tumor.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100018
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Aspectos clínico e cirúrgicos do tumor mamário canino: clinical and surgical evolution Ciência Rural
Daleck,Carlos Roberto; Franceschini,Paulo Henrique; Alessi,Antonio Carlos; Santana,Áureo Evangelista; Martins,Maria Izabel Mello.
As neoplasias mamárias em cadelas representam importante parcela das neoplasias em cães, merecendo atenção dos pesquisadores quanto ao diagnóstico, tratamento e prognóstico. No presente trabalho, 23 cadelas de várias raças ou cruzamentos, com idades entre 8 e 11 anos portadoras de neoplasia mamária foram estudadas. Doze eram multíparas, 6 primíparas e 5 nulíparas. Todas eram da região de Jaboticabal, SP, atendidas no Hospital Veterinário da FCAVJ-UNESP. Os animais foram avaliados clínica e radiolagicamente e submetidos à punção aspirativa da massa anormal de tecido, com agulha fina. Dessa mesma massa foi também retirado, cirurgicamente, um fragmento para exame histopatológico. A maior incidência foi de carcinoma (52,17%), seguidos por tumores mistos...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cão; Tumor; Mama; Quimioterapia; Cirurgia.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84781998000100016
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Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy Biol. Res.
Rosas,Carlos; Sinning,Mariana; Ferreira,Arturo; Fuenzalida,Marcela; Lemus,David.
BACKGROUND: During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic effects. However, the effects of this drug on a tumor cell line resistant to chemotherapeutical drugs used in cancer have not been described. Herein we evaluate the angiogenic and antitumor effects of Cx in the development of a drug-resistant mammary adenocarcinoma tumor (TA3-MTXR). RESULTS: Cx reduces angiogenesis in the chick embryonic chorioallantoic membrane assay (CAM), inhibits the growth and microvascular density of the murine TA3-MTXR tumor, reduces microvascular density of tumor metastases, promotes apoptosis and reduces...
Tipo: Journal article Palavras-chave: Angiogenesis; Celecoxib; Tumor.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100027
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Ceratites, ceratoconjuntivites e tumores de olhos em ovinos e caprinos, suas prováveis causas e implicações. Infoteca-e
SILVA, M. U. D. e; SILVA, E. D. F. da..
Tipo: Circular Técnica (INFOTECA-E) Palavras-chave: Ceratoconjuntivite; Doença oftalmológica; Caprino; Ovino; Doença animal; Ceratite; Olho; Tumor; Goats; Animal diseases; Ophthalmic diseases; Keratoconjunctivitis; Keratitis; Eye diseases.
Ano: 1983 URL: http://www.infoteca.cnptia.embrapa.br/handle/doc/514768
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Choroid plexus papilloma in a Rottweiler: computed tomographic, gross morfological and histological features Arq. Bras. Med. Vet. Zootec.
Pinto,A.C.B.C. Fonseca; Villamizar,L.A.; Ghirelli,C.O.; Silva,T.R.C.; Baroni,C.O.; Banon,G.P.R.; Guerra,J.M.; Amaral,C.T.; Torres,L.N..
Among the tumors affecting the choroid plexus in dogs, the papilloma ranks second place in incidence after cell carcinoma tumors. Presumptive diagnosis can be made through imaging methods, such as computed tomography and magnetic resonance images. Definitive diagnosis of plexus choroid tumor is based on histopathological findings. This report presented the tomographic features of the brain in a 6-year-old intact female Rottweiler with choroid plexus papilloma. The computed tomography showed right lateral ventricle enlargement, midline deviation and an enhanced mass into the postcontrast phase. At necropsy, a mass on the floor of the right lateral ventricle was observed, associated with important ventricle dilatation. The histopathological analysis...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dog; Computed tomography; Choroid plexus; Tumor.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352013000300023
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Classification of brain tumor extracts by high resolution ¹H MRS using partial least squares discriminant analysis BJMBR
Faria,A.V.; Macedo Jr.,F.C.; Marsaioli,A.J.; Ferreira,M.M.C.; Cendes,F..
High resolution proton nuclear magnetic resonance spectroscopy (¹H MRS) can be used to detect biochemical changes in vitro caused by distinct pathologies. It can reveal distinct metabolic profiles of brain tumors although the accurate analysis and classification of different spectra remains a challenge. In this study, the pattern recognition method partial least squares discriminant analysis (PLS-DA) was used to classify 11.7 T ¹H MRS spectra of brain tissue extracts from patients with brain tumors into four classes (high-grade neuroglial, low-grade neuroglial, non-neuroglial, and metastasis) and a group of control brain tissue. PLS-DA revealed 9 metabolites as the most important in group differentiation: γ-aminobutyric acid, acetoacetate, alanine,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brain; Tumor; Magnetic resonance spectroscopy; Spectroscopy; Metabolism.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200009
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Cytological and histopathological aspects of lipomas in Bothrops moojeni Arq. Bras. Med. Vet. Zootec.
Cassali,G.D.; Amaral,V.F.; Silva,A.E.; Macri,I.; Maciel,R..
O presente relato descreve os achados citológicos e histológicos de seis neoplasias benignas em cinco ofídios da espécie Bothrops moojeni mantidas em cativeiro por um período médio de 11,4 anos. Os animais apresentavam nódulos subcutâneos com localização variada desde o terço anterior até a porção mediana. Os exames citológico e histopatológico revelaram tratar-se de tumores lipomatosos benignos compatíveis com o subtipo lipoma fusocelular.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bothrops moojeni; Lifoma; Tumor; Neoplasm.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000600017
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Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone Genet. Mol. Biol.
Baruffi,Marcelo Razera; Barbieri-Neto,J.; Pina-Neto,João Monteiro; Suerzut,C.E.; Casartelli,Cacilda.
Cytogenetic analyses were performed on a bone giant cell reparative granuloma (GCRG) and on three bone giant cell tumors (GCT). The present GCRG case is the second to be described cytogenetically. A modal chromosome number of 46 was observed in all samples. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes 17 and 18. Among the structural anomalies observed, there was preferential involvement of chromosomes 6 and 10. Three GCT cases presented del(10)(p13) and two cases presented del(6)(q25) (1 GCRG and 1 GCT). These breakpoints mapped on 10p and 6q may harbour genes of importance in the development of bone giant cell tumors.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bone; Giant-cell; Granuloma; Tumor; Chromosome.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000300002
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Efecto de Celecoxib en una Variante Multirresistente del Tumor TA3: Una Descripción Histológica International Journal of Morphology
Rosas C,Carlos; Roa,Ignacio; Sinning O,Mariana; Fuenzalida B,Marcela; Lemus A,David.
En el estudio del cáncer, se utilizan diversas líneas celulares, cada una de ellas con características propias. Una de esas líneas tumorales es la variante multirresistente a drogas del tumor TA3. Si bien, existen diversos estudios con esta línea tumoral, no existe una descripción morfológica detallada de esta, ni tampoco que se observe el efecto del Celecoxib, un inhibidor de COX-2 sobre este tejido. Se usaron 18 ratones divididos en 3 grupos, los cuales recibieron: Inoculación de PBS; inoculación de células tumorales TA3; inoculación de células tumorales + tratamiento con Celecoxib (1000 ppm), respectivamente. Los ratones fueron sacrificados y procesados histológicamente para ser teñidos con H&E, PAS y Arteta. El estudio reveló que tumor muestra una...
Tipo: Journal article Palavras-chave: Tumor; Angiogénesis; Celecoxib.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200005
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Effect of Curcuma zedoaria crude extract against tumor progression and immunomodulation J. Venom. Anim. Toxins incl. Trop. Dis.
Carvalho,FR; Vassão,RC; Nicoletti,MA; Maria,DA.
The aim of the present work was to study the effect of the crude extract of Curcuma zedoaria on peripheral blood cells and tumor progression in C57Bl/6J mice injected with B16F10 murine melanoma cells. The intraperitoneal therapy showed a significant increase in total white and red blood cell counts, a decrease in peritoneal cell number and tumor volume reduction, whereas the oral administration revealed a noteworthy augmentation only in total leukocyte count. These results contribute to evaluate the importance of alternative treatments that employ phytotherapic compounds against tumor progression and its possible immunomodulation.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Melanoma; Tumor; Hematology; Curcuma zedoaria.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200013
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Effects of Steroidal and Non Steroidal Drugs on the Neovascularization Response Induced by Tumoral TA3 Supernatant on CAM from Chick Embryo Biol. Res.
ZÚÑIGA,JORGE; FUENZALIDA,MARCELA; GUERRERO,ANÍBAL; ILLANES,JULIO; DABANCENS,ALFREDO; DÍAZ,EUGENIA; LEMUS,DAVID.
Angiogenesis, the development of new blood vessels from the existing vascular network, may result as a consequence of the increase or decrease of proangiogenic or antiangiogenic factors, respectively. The tumor itself could up-regulate the production of angiogenic factors. Recently, we established that the steroidal drug betamethasone in low concentration inhibit the neovascularization promoted by TA3 Ts on CAM of chick embryos. We describe here the effects of the non-steroidal drug ketoprofen, alone or in association with betamethasone, on the angiogenesis promoted by TA3 Ts on CAM. The main finding reported here is that the formation of new blood vessels is strongly inhibited by low concentrations of ketoprofen. The association of both drugs produced a...
Tipo: Journal article Palavras-chave: Angiogenesis; Antiangiogenesis; Tumor; Betamethasone; Ketoprofen.
Ano: 2003 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200013
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Endoscopic approach for a laryngeal neoplasm in a dog Ciência Rural
Teixeira,Pedro Paulo Maia; Souza,Erica Siqueira; Jark,Paulo César; Coutinho,Leandro Nassar; Silva,Alanna do Socorro Lima da; Guiduce,Marcos Vinicius Sicca; Maria,Bruna Piva; Silva,Paloma Espirito Santo; Semolin,Lívia Maria Souza; Silva,Marco Augusto Machado; Vicente,Wilter Ricardo Russiano; Tinucci-Costa,Mirela; Nardi,Andrigo Barboza De.
Laryngeal and tracheal tumors are rare in pets; some piece of information on their disease behavior, therapy and evolution are limited. Neoplasms in this area are a diagnostic challenge. In many cases, they can be biopsied and excised using endoscopic instruments, but there is no report of this in canines. The goal of this study is to report a successful case of a laryngeal neoplasm removal through endoscopy. A head and neck radiogram revealed a mass in the laryngeal lumen protruding into the trachea. The patient then underwent an endoscopy to confirm the radiographic diagnosis and to surgically remove the tumor. The histopathological diagnosis was poorly differentiated carcinoma. The most appropriate treatment for laryngeal tumors is the resection of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tumor; Larynx; Canine; Endoscopy.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000100131
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Etude d'une prolifération hémocytaire chez la moule Mytilus edulis ArchiMer
Noel, Danièle.
Hemic proliferative disease in the bay mussel, Mytilus edulis, has been studied following mortalities in Washington State (USA). The disease has been reproduced in the labortory. The establishment of this experimental model led to study tumoral characteristics of the atypic hemocytes : ultrastrure, in vitro cultivation, transplantation. The infectious etiology of this tumor has been verified. It has been hypothesized to result from a viral infection since retrovirus-like particules have been observed following induction by bromodeoxyuridine. Specific monoclonal antibodies against atypic hemocytes have been obtained and characcterized
Tipo: Text Palavras-chave: Mytilus; Mollusque; Hémocyte; Tumeur; Ulstrastructure; In vitro culture; Transplantation; Rétrovirus; Anticorps monoclonaux; Mytilus; Mollusca; Hemocyte; Tumor; Ultrastructure; In vitro cultivation; Transplantation; Retrovirus; Monoclonal antibodies.
Ano: 1988 URL: http://archimer.ifremer.fr/doc/00428/53930/55057.pdf
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Insulinoma canino: relato de caso Arq. Bras. Med. Vet. Zootec.
Padovani,L.; Silva,D.D.; Moreira,J.R.; Cardoso,M.J.L.; Santis,G.W. Di; Zanutto,M.S..
RESUMO O insulinoma é um tumor das células β do pâncreas, que têm a função de produzir e secretar insulina e, geralmente são malignos em cães. O presente trabalho descreve o diagnóstico e o manejo terapêutico de três casos de insulinoma. Os sinais clínicos dos animais relatados variaram de acordo com a severidade e a duração da hipoglicemia. O diagnóstico presuntivo se deu através dos sinais clínicos e da dosagem de insulina sérica no momento de mais intensa hipoglicemia e, o diagnóstico definitivo foi obtido por meio de exame histopatológico nos três casos relatados. O tratamento realizado variou de acordo com a intensidade dos sinais clínicos.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tumor; Células β; Hipoglicemia.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000601466
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Leiomiossarcoma gástrico associado a hérnia de hiato em cão da raça Shar-pei: relato de caso Arq. Bras. Med. Vet. Zootec.
Prado,L.O.C.; Franco,G.G.; Legatti,E.; Ranzani,J.J.T.; Quitzan,J.G.; Siqueira,E.G.M.; Souza,J.A.L.; Minto,B.W.; Brandão,C.V.S..
RESUMO Os tumores do sistema digestório não são comuns na medicina veterinária e as neoplasias de estômago representam menos de 1% de todos os tumores malignos. O leiomiossarcoma é o segundo tumor que mais acomete o trato gastrointestinal de cães, com predisposição para as regiões de jejuno e ceco, mas qualquer porção pode ser afetada, desde o esôfago até o reto. O presente trabalho relata um caso em um canino da raça Shar-pei, macho, com 13 anos de idade e histórico de episódios eméticos pós- prandiais e emagrecimento progressivo havia oito meses. Após avaliação radiográfica e endoscópica, foi indicada intervenção cirúrgica e observada tumoração gástrica associada a hérnia de hiato. O diagnóstico de leiomiossarcoma gástrico foi estabelecido por meio de...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cirurgia; Estômago; Oncologia; Tumor.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000100111
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Metastatic well differentiated squamous cell carcinoma in the prepuce of a dog: a report of clinicopathological, immunophenotypic and therapeutic approach Arq. Bras. Med. Vet. Zootec.
Auler,P.A.; Gamba,C.O.; Horta,R.S.; Lavalle,G.E.; Cassali,G.D..
This report describes a case of a well differentiated squamous cell carcinoma (SCC) of the foreskin of a dog, with metastasis in the regional lymph node. A six-year-old male intact Pit Bull dog presented a preputial ulcerated lesion with an evolution time of one year and enlarged left inguinal lymph node. Surgical resection of the preputial lesion and inguinal lymph nodes was made. The diagnosis of a well differentiated SCC was made following histopathological analysis and immunohistochemistry technique was used to confirm lymph node metastasis and to determine the histological features of the tumor. Here we demonstrated that immunohistochemistry can be an important complementary diagnostic tool to assess the prognostic features of SCC and to determine the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Metastasis; Tumor; Skin; Immunohistochemistry; Chemotherapy.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000501317
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Neuropathic pain and prognosis of a dog submitted to limb amputation after diagnosis of soft tissue sarcoma - case report Arq. Bras. Med. Vet. Zootec.
Ferreira,M.G.P.A.; Antunes,A.V.; Pascoli,A.L.; Nazaret,T.L.; Gering,A.P.; Reis Filho,N.P.; Costa,M.T.; Nardi,A.B..
ABSTRACT Neuropathic pain occurs when there is a lesion or a dysfunction of the nervous system. Humans and veterinary patients may develop neuropathic pain, but in veterinary it is not often reported probably because of its mistaken diagnosis. A canine patient was admitted to the Veterinary Hospital of UNESP-Jaboticabal-SP, Brazil with a nodule on the left thoracic limb. The nodule was surgically removed, and histopathological analysis demonstrated the tumor was a soft tissue sarcoma (STS) and the margins were not clean. Based on the patient’s health condition and the lack of suitable equipment, the next procedure was limb amputation. The patient received analgesic medication in the post-surgery period; nevertheless, clinical signs of neuropathic pain were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Analgesia; Oncology; Phantom limb; Radiotherapy; Tumor.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000401116
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Qualidade diagnóstica da biópsia com agulha Super-core II® de nódulos mamários de cadelas Ciência Rural
Pliego,Cristina Mendes; Ferreira,Maria de Lourdes Gonçalves; Ferreira,Ana Maria Reis; Chaudon,Marília Botelho de Oliveira.
A biópsia com agulha de corte é um método fácil e rápido para obtenção de um fragmento do tumor, e amplamente utilizado no diagnóstico de lesões mamárias em mulheres. O objetivo do estudo foi realizar a avaliação diagnóstica da biópsia em 26 nódulos mamários de 19 cadelas, utilizando a agulha de corte Super-core II® 14-ga x 9cm. Após a biópsia, os pacientes foram submetidos à mastectomia para obtenção dos nódulos mamários. As amostras da biópsia e os nódulos foram analisados histopatologicamente e as neoplasias foram classificadas segundo a Organização Mundial de Saúde (OMS). A biópsia com agulha mostrou sensibilidade de 100% e especificidade de 71,4% no diagnóstico de adenocarcinomas, e no diagnóstico de carcinossarcomas mostrou 71,4% de sensibilidade e...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Biópsia com agulha de corte; Tumor; Mama.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782008000800018
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Renal cell carcinoma with peritoneal carcinomatosis in a mare Ciência Rural
Mesquita,Leonardo Pereira; Mesquita Neto,Francisco Duque de; Varaschin,Mary Suzan; Wouters,Angélica Terezinha Barth; Wouters,Flademir.
ABSTRACT: Renal cell carcinoma, especially with extensive involvement of peritoneal cavity, is rarely described in horses. This study described a case of renal cell carcinoma in an 8-year-old mare, which presented with an enlargement in the left flank, decreased appetite and straining to defecate. Clinically, a tumor in the left retroperitoneal space was detected by rectal examination and ultrasonography. The animal died after one month of clinical evolution. At necropsy, the left kidney was completely effaced by a 50cm in diameter, irregular, round, lobulated cystic mass with necro-hemorrhagic areas. Within the peritoneal cavity, there was severe hemoperitoneum and numerous sessile and pedunculated masses ranging from 2.0 to 15.0cm diameter that were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Equine; Renal neoplasia; Pathology; Kidney; Tumor.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000100602
Registros recuperados: 26
Primeira ... 12 ... Última
 

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