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ANTITUMOR EFFECT OF SNAKE VENOMS J. Venom. Anim. Toxins
SILVA,R. J. DA; FECCHIO,D.; BARRAVIERA,B..
The search for biological antitumor agents has been pursued for over half a century. Snake venom has been shown to possess a wide spectrum of biological activities. The objectives of the present review are to evaluate the existing controversies on this subject published in a number of papers and to propose probable explanations for the phenomena observed. We reported our results obtained in a study, in which we evaluated the action of the venoms of Crotalus durissus terrificus and Bothrops jararaca on Ehrlich ascites tumor cells. We noticed an important antitumor effect, mainly with Bothrops jararaca venom, as well as an increase in the functional activity of macrophages. We also observed an increase in the number of mononuclear and polymorphonuclear cells...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Inflammation; Venom; Snakes; Crotalus durissus terrificus; Bothrops jararaca.
Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301996000200002
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BIOINSECTICIDE ACTION OF THE VENOM OF AFRICANIZED BEES Apis mellifera LINNAEUS 1758 (HYMENOPTERA: APIDAE): I -THE MOST SUSCEPTIBLE AGE OF Diatraea saccharalis FABRICIUS 1794 (LEPELETIER: PYRALIDAE) EGGS TO THE VENOM ACTION J. Venom. Anim. Toxins
BONFANTI-ALMEIDA,J.C.; GOBBI,N.; PALMA,M.S..
The present paper aimed at testing the action of non-lyophilized venom of Africanized bees Apis mellifera through topical applications on Diatraea saccharalis egg masses. The CL50, DL50 and the most susceptible age of eggs to the venom topic application were also determined. Three-day-old eggs were the most susceptible to the venom action with CL50 equal to 8.6 mg/ml and DL50 equal to 0.173 mg/mass. The venom loses its action after being stored for 15 days.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Venom; Africanized bee; Apis mellifera; Eggs; Sugar-cane borer; Diatraea saccharalis.
Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301996000100006
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EFFECT OF Crotalus durissus terrificus (LAURENTI, 1768) VENOM ON THE EVOLUTION OF EHRLICH ASCITES TUMOR J. Venom. Anim. Toxins
SILVA,R. J. DA; FECCHIO,D.; BARRAVIERA,B..
The effect of Crotalus durissus terrificus (LAURENTI, 1768) venom on the evolution of Ehrlich ascites tumor cells was evaluated. Thus, 30-day-old male mice of the Swiss strain were inoculated intraperitoneally with 1x10<img SRC="http:/img/fbpe/jvat/v3n2/image1947.gif"> tumor cells. Then, 7 groups of animals were formed: 3 control groups (physiological, venom and tumor) and 4 experimental groups that received different doses of venom. The experimental groups received 5 intraperitoneal venom injections on the 1<img SRC="http:/img/fbpe/jvat/v3n2/image1948.gif"> , 4<img SRC="http:/img/fbpe/jvat/v3n2/image1949.gif"> , 7<img SRC="http:/img/fbpe/jvat/v3n2/image1949.gif"> , 10<img SRC="http:/img/fbpe/jvat/v3n2/image1949.gif"> and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Venom; Inflammation; Tumor growth; Crotalus durissus terrificus.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000200008
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Hymenoptera venom review focusing on Apis mellifera J. Venom. Anim. Toxins incl. Trop. Dis.
Lima,P. R. de; Brochetto-Braga,M. R..
Hymenoptera venoms are complex mixtures containing simple organic molecules, proteins, peptides, and other bioactive elements. Several of these components have been isolated and characterized, and their primary structures determined by biochemical techniques. These compounds are responsible for many toxic or allergic reactions in different organisms, such as local pain, inflammation, itching, irritation, and moderate or severe allergic reactions. The most extensively characterized Hymenoptera venoms are bee venoms, mainly from the Apis genus and also from social wasps and ant species. However, there is little information about other Hymenoptera groups. The Apis venom presents high molecular weight molecules - enzymes with a molecular weight higher than...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hymenoptera; Venom; Enzymes; Peptides.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992003000200002
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Insects as biological models to assay spider and scorpion venom toxicity J. Venom. Anim. Toxins incl. Trop. Dis.
Manzoli-Palma,M. F.; Gobbi,N.; Palma,M. S..
This study was undertaken to develop an experimental protocol using insects as biological models to assay venom toxicity of the following spiders Loxosceles gaucho, Phoneutria nigriventer, Nephilengys cruentata and Tityus serrulatus scorpion. Three different insect species were bioassayed: Apis mellifera (Hymenoptera), Grillus assimilis (Orthoptera), and Diatraea saccharalis (Lepidoptera). Venoms were injected into the hemocele of insects with a microsyringe at concentrations that caused dose/weight-dependent effects; doses causing either paralysis (ED50) or death (LD50) were recorded for each venom and insect test-species. T. serrulatus and L. gaucho venoms were lethal to all tested species, while P. nigriventer venom caused paralysis and death, and N....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bioassay; Venom; Insect model; Toxicity; Apis mellifera.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992003000200004
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Maintenance of scorpions of the genus Tityus Koch (Scorpiones, Buthidae) for venom obtention at Instituto Butantan, São Paulo, Brazil J. Venom. Anim. Toxins incl. Trop. Dis.
Candido,D. M.; Lucas,S..
This work presents the experience of the Laboratory of Arthropods at Instituto Butantan, which maintains scorpions in captivity in order to obtain the venom used in the production of anti-arachnid serum. Between 1993 and 2000, the laboratory received 24.781 specimens of Tityus serrulatus in order to obtain poison for the production of anti-scorpion serum. In the first extraction, performed by electrical stimulation, the animals gave an average quantity of 0.4 mg venom per specimen. Animal acquisition and involved professional safety are considered. In addition, the captivity, handling and feeding techniques are described, as well as the method and equipment used for venom extraction. It shows the importance of regular campaigns, offering information to the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpions; Tityus; Maintenance; Venom.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992004000100007
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MOLECULAR EXCLUSION CHROMATOGRAPHY OF CRUDE VENOM AS AN AUXILIARY TOOL TO IDENTIFY HYBRID HONEYBEE POPULATIONS J. Venom. Anim. Toxins
PALMA,M.S.; BROCHETTO-BRAGA,M.R.; CHAUD-NETTO,J.; MALASPINA,O.; OLIVEIRA,M.R..
A comparison among the profiles of molecular exclusion chromatography in Sephadex G 100 column of venoms from Apis mellifera adansonii and Africanized honeybees revealed unique peaks which might be used to identify these populations. The venoms from hybrid populations resulting from the reciprocal mating of Apis mellifera adansonii and Africanized honeybees presented unique peaks, probably resulting from a synergistic effect between the parental genomes. The occurrence of characteristic peaks in venoms of hybrid populations might be used to identify these populations as well as to distinguish them from their parents.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apis mellifera; Venom; Hybrid populations; Molecular exclusion chromatography; Honeybees.
Ano: 1995 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301995000100004
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Notes of cases of aggression and ophiophagy by Bothops jararacussu (Lacerda 1884) in captivity Acta Toxicol. Argent.
de Roodt,Adolfo R; Lanari,Laura C.
Bothrops jararacussu is one of the most venomous snakes of medical importance in South America, mainly due to the toxicity of their venom and the large amount of that which can be injected in a single bite. The venom of this snake is required for the production, process and control of the therapeutic antivenoms used to treat Bothrops envenomation, so it is one of the Bothrops species common in Serpentariums located in Argentina and Brazil dedicated to the production of antivenoms. We reported two cases of ophiophagy due captive adult B. jararacussu females on Bothrops and Philodryas snakes and the aggression of specimens of this species is also described. Despite well known resistance to homologous venom of Bothrops species, the bite of this specie on...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Ophiophagy; Natural resistance; Bite; Venom.
Ano: 2015 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432015000300004
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PRELIMINARY INVESTIGATION ABOUT THE ANTI-COMPLEMENT PROPERTIES OF PARTIALLY SEPARATED Vipera ammodytes VENOM J. Venom. Anim. Toxins
STANILOVA,S.; ZHELEV,Z.; MATEV,I..
The present study demonstrates that Vipera ammodytes venom is a potent inhibitor of human complement activation. Crude venom was fractionated by ion-exchange chromatography and each fraction was then tested for proteolytic, hemolytic and anti-complement activities. Three peaks decreased the hemolytic activity of human serum when measured using assays for the classical and alternative pathways of activation. One of the anti-complement peaks contains a protease capable of cleaving the C3 component of complement.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Anti-complement; Venom; Vipera ammodytes.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000100005
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Purification and partial characterization of phospholipases A2 from Bothrops asper (barba amarilla) snake venom from Chiriguaná (Cesar, Colombia) J. Venom. Anim. Toxins incl. Trop. Dis.
Ramírez-Avila,J.; Quevedo,B. E.; López,E.; Renjifo,J. M..
Components with phospholipase A2 activity were isolated by gel filtration and cationic exchange chromatography from the venom of Bothrops asper snakes from Chiriguaná, Colombia (9°22´N; 73°37´W). Five fractions were obtained by the gel filtration, and PLA2 activity was found in fraction 3 (F3). In the cationic exchange chromatography, F3 showed eight components with PLA2 activity. Six of these components appeared as one band in polyacrylamide gel electrophoresis (SDS-PAGE). Fractions II and VII exhibited an optimal activity at pH 9 and 52ºC. The optimum calcium concentration for fraction II was 48 mM and for fraction VII, 384 mM. Both fractions showed thermal stability. Fraction II was stable at pH values between 2.5 and 9, and fraction VII, between 2.5...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phospholipase; Isoenzymes; Snake; Venom; Bothrops asper; Colombia.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992004000300005
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Snake venom metalloproteinases and disintegrins: interactions with cells BJMBR
Kamiguti,A.S.; Zuzel,M.; Theakston,R.D.G..
Metalloproteinases and disintegrins are important components of most viperid and crotalid venoms. Large metalloproteinases referred to as MDC enzymes are composed of an N-terminal Metalloproteinase domain, a Disintegrin-like domain and a Cys-rich C-terminus. In contrast, disintegrins are small non-enzymatic RGD-containing cysteine-rich polypeptides. However, the disintegrin region of MDC enzymes bears a high degree of structural homology to that of the disintegrins, although it lacks the RGD motif. Despite these differences, both components share the property of being able to recognize integrin cell surface receptors and thereby to inhibit integrin-dependent cell reactions. Recently, several membrane-bound MDC enzymes, closely related to soluble venom MDC...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Venom; Metalloproteinase; Disintegrin; Platelet; Integrin; Signaling.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700001
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USE OF AN ELISA ASSAY TO EVALUATE VENOM, ANTIVENOM, IgG AND IgM HUMAN ANTIBODY LEVELS IN SERUM AND CEREBROSPINAL FLUID FROM PATIENTS BITTEN BY Crotalus durissus terrificus IN BRAZIL J. Venom. Anim. Toxins
BARRAVIERA,B.; SARTORI,A.; PEREIRA DA SILVA,M. F.; KANENO,R.; PERAÇOLI,M. T. S..
A sandwich-type ELISA technique for specific and sensitive detection of Crotalus durissus terrificus venom antigens, horse-antivenom, human IgG and IgM antibodies was set up. Sixteen patients, 13 males and 3 females aged between 13 to 63 years (mean 33 ± 15) bitten by Crotalus durissus terrificus snakes were studied. Of the 15 patients, 6 had previously received anti-Crotalus venom and no seric venom was detected. For the other 9 patients studied, the venom levels ranged from 2 to 108 ng/ml according to the severity of each case. Seric antivenom was detected up to 44 days after the bite. IgM human antibody levels against Crotalus venom were higher between 3 and 18 days after specific treatment. IgG human antibody levels against Crotalus venom were detected...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Enzyme-linked immunosorbent assay; Crotalus durissus terrificus; Venom; Antivenom; Antibodies; Cerebrospinal fluid.
Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301996000100003
Registros recuperados: 12
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