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Provedor de dados:  Repositório Alice
País:  Brazil
Título:  In silico phylogenetic and virulence gene profile analyses of avian pathogenic Escherichia coli genome sequences.
Autores:  ROJAS, T. C. G.
Data:  2017-10-17
Ano:  2014
Palavras-chave:  Árvore filogenética
Avian pathogenic Escherichia coli
Tipagem de sequência multilocus
Análise in silico
Genes associados à virulência
Multi-locus Sequence Typing
Phylogenetic tree
Virulence genes.
Escherichia Coli.
Resumo:  Avian pathogenic Escherichia coli (APEC) infections are responsible for significant losses in the poultry industry worldwide. A zoonotic risk has been attributed to APEC strains because they present similarities to extraintestinal pathogenic E. coli (ExPEC) associated with illness in humans, mainly urinary tract infections and neonatal meningitis. Here, we present in silico analyses with pathogenic E. coli genome sequences, including recently available APEC genomes. The phylogenetic tree, based on multi-locus sequence typing (MLST) of seven housekeeping genes, revealed high diversity in the allelic composition. Nevertheless, despite this diversity, the phylogenetic tree was able to cluster the different pathotypes together. An in silico virulence gene profile was also determined for each of these strains, through the presence or absence of 83 well-known virulence genes/traits described in pathogenic E. coli strains. The MLST phylogeny and the virulence gene profiles demonstrated a certain genetic similarity between Brazilian APEC strains, APEC isolated in the United States, UPEC (uropathogenic E. coli) and diarrheagenic strains isolated from humans. This correlation corroborates and reinforces the zoonotic potential hypothesis proposed to APEC.
Tipo:  Artigo de periódico
Idioma:  Inglês
Identificador:  Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 34, n. 2, p. 129-133, fev. 2014.
Direitos:  openAccess

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