| Registro completo |
| Provedor de dados: |
Nature Precedings
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| País: |
United Kingdom
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| Título: |
DNA expression microarrays may be the wrong tool to identify biological pathways
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| Autores: |
Adrian Mondry
Marie Loh
Alessandro Giuliani
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| Data: |
2007-09-18
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| Ano: |
2007
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| Palavras-chave: |
Biotechnology
Genetics & Genomics
Molecular Cell Biology
Pharmacology
Bioinformatics
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| Resumo: |
DNA microarray expression signatures are expected to provide new insights into patho- physiological pathways. Numerous variant statistical methods have been described for each step of the signal analysis. We employed five similar statistical tests on the same data set at the level of gene selection. Inter-test agreement for the identification of biological pathways in BioCarta, KEGG and Reactome was calculated using Cohen’s k- score. The identification of specific biological pathways showed only moderate agreement (0.30 < k < 0.79) between the analysis methods used. Pathways identified by microarrays must be treated cautiously as they vary according to the statistical method used.
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| Tipo: |
Manuscript
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| Identificador: |
http://precedings.nature.com/documents/1036/version/1
oai:nature.com:10.1038/npre.2007.1036.1
http://dx.doi.org/10.1038/npre.2007.1036.1
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| Fonte: |
Nature Precedings
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| Direitos: |
Creative Commons Attribution 3.0 License
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