| Registro completo |
| Provedor de dados: |
Nature Precedings
|
| País: |
United Kingdom
|
| Título: |
Formulation and in vitro Evaluation of Eudragit L100 piroxicam
|
| Autores: |
Mostafa Saffari
Malihe Shahbazi
Mehdi Shafiee Ardestani
|
| Data: |
2008-01-27
|
| Ano: |
2008
|
| Palavras-chave: |
Chemistry
Pharmacology
|
| Resumo: |
The aim of this study was to formulate and evaluate controlled release preparations of a water-insoluble drug using Copolymers synthesized from acrylic and methacrylic acid
esters (Eudragit L 100) as the retardant material. Microspheres were prepared by solvent evaporation method using an alcohol / liquid paraffin system. Span60 was used as the droplet stabilizer. The prepared microspheres were characterized for their micromeritic properties and drug loading, as well as by differential scanning calorimetry. The in vitro release studies were performed first in pH1.2 and then pH 6.8, phosphate buffer. The prepared microspheres were yellow, and spherical in shape. The drugloaded microspheres showed 71-85% of entrapment and release was extended up to 7 h. The differential scanning calorimetry thermographs showed stable character of drug in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. The best-fit release kinetics was achieved with Higuchi plot. The release of drug was influenced by the drug to polymer ratio and particle size that was found to be diffusion controlled.

|
| Tipo: |
Manuscript
|
| Identificador: |
http://precedings.nature.com/documents/1544/version/1
oai:nature.com:10.1038/npre.2008.1544.1
http://dx.doi.org/10.1038/npre.2008.1544.1
|
| Fonte: |
Nature Precedings
|
| Direitos: |
Creative Commons Attribution 3.0 License
|
