| Resumo: |
The nematode worm, _Caenorhabditis elegans_, was the first multicellular organism to be sequenced. Its genome was published in 1998, providing an impetus for gene and protein annotation. Recently, the genome of _C. briggsae_ has been sequenced. This has given bioinformaticans the opportunity to study comparative genomics between two highly similar organisms. Currently, there are 12 species of _Caenorhabditis_ in UniProtKB and over 700 nematode species, including some of interest to parasitology. Functional and sequence annotation from literature and sequence analysis tools are included in each curated record. _C. elegans_ has a relatively small genome size, short life span and a transparent body, making it ideal for knock-out/RNAi studies. Thus many _C. elegans_ UniProtKB entries have characterization details in the newly introduced DISRUPTION PHENOTYPE comment. Many more worm genome sequencing projects are underway, three of which involve species from the _Caenorhabditis_ genus (_C. brenneri_, _C. japonica_ and _C.remanei_). We look forward to working with this influx of data and continuing our close collaboration with WormBase.
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