| Registro completo |
| Provedor de dados: |
Nature Precedings
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| País: |
United Kingdom
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| Título: |
Ciproxifan, an H~3~ Receptor Antagonist, Improves Learning and Memory in the APP Mouse Model of Alzheimer's Disease
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| Autores: |
Mark E. Bardgett
Natasha N. Davis
Molly S. Griffith
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| Data: |
2009-12-02
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| Ano: |
2009
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| Palavras-chave: |
Neuroscience
Pharmacology
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| Resumo: |
Mice that express the mutant form of the human amyloid precursor gene associated with early-onset familial Alzheimer's disease demonstrate memory deficits and amyloid plaques. We show here that ciproxifan, a prototypical antagonist of H~3~-type histamine receptors, alleviates two types of learning and memory impairments in such mice. These data support the idea that modulation of H~3~ receptors represents a viable therapeutic strategy in the treatment of Alzheimer's disease.
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| Tipo: |
Manuscript
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| Identificador: |
http://precedings.nature.com/documents/4041/version/1
oai:nature.com:10101/npre.2009.4041.1
http://hdl.handle.net/10101/npre.2009.4041.1
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| Fonte: |
Nature Precedings
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| Direitos: |
Creative Commons Attribution 3.0 License
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