| Registro completo |
| Provedor de dados: |
Nature Precedings
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| País: |
United Kingdom
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| Título: |
Deletion of the trpc4 gene and its role in simple and complex strategic learning
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| Autores: |
William D. Klipec
Phuong Nguyen
Bridget Deeney
Claire Williamson
Kami Wenzel
Jessica Stumme
Marissa Collins
Abby Drish
Laura Swenson
Eric Ostertag
Donald C. Cooper
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| Data: |
2012-02-24
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| Ano: |
2012
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| Palavras-chave: |
Neuroscience
Pharmacology
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| Resumo: |
The TRPC4 ion channel is expressed extensively in corticolimbic and a subpopulation of midbrain dopamine neurons. While TRPC4 knockout (KO) rats exhibit reduced sociability and social exploration, little is known about the role of TRPC4 in motivation and learning. To identify a function for TRPC4 channels in learning processes  we tested TRPC4 KO and normal wild type (WT) rats. TRPC4 KO and WT rats exhibited no differences in Y-­maze learning or simple discrimination learning. Furthermore, on a more complex serial reversal shift task designed  to assess strategic learning where the reward and non-­reward cues were repeatedly reversed between training sessions both TRPC4 KO and WT rats   performed equally well. Finally, we found no   performance differences when using a conditional reversal shift task where a tone signals the reversal of reward and non-reward cues within sessions. These data suggest that although TRPC4 channels may play a role in social interaction/anxiety  they exert a minimal role in simple and complex strategic learning.
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| Tipo: |
Manuscript
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| Identificador: |
http://precedings.nature.com/documents/6929/version/1
oai:nature.com:10.1038/npre.2012.6929.1
http://dx.doi.org/10.1038/npre.2012.6929.1
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| Fonte: |
Nature Precedings
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| Direitos: |
Creative Commons Attribution 3.0 License
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