| Registro completo |
| Provedor de dados: |
OAK
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| País: |
Japan
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| Título: |
Overexpression of Interleukin 2 Receptor, Thymidine Kinase and Immunoglobulin-Associated Alpha-1 Messenger RNA in a Clinical Case of Enzootic Bovine Leukosis
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| Autores: |
TAWFEEQ, Mohammad Monir
TAGAWA, Michihito
ITOH, Yuuki
SUGIMOTO, Kazuya
KOBAYASHI, Yoshiyasu
INOKUMA, Hisashi
古林, 与志安
猪熊, 壽
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| Data: |
2012
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| Ano: |
2012
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| Palavras-chave: |
Biomarker
Bovine leukosis
Gene expression
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| Resumo: |
A 49-month-old Holstein cow with anorexia, tachypnea, enlarged peripheral lymph nodes, and difficulty standing up was suspected of bovine leukosis. Hematological examination revealed lymphocytosis with the presence of neoplastic cells. Increased total lactate dehydrogenase (LDH) activity, isozymes of LDH-2 and LDH-3 activities and thymidine kinase activity were observed. Cytological findings of fine needle aspiration of subiliac lymph nodes indicated lymphosarcoma. Histopathology and antibody analysis confirmed the diagnosis of enzootic bovine leukosis, a B-cell bovine lymphoma caused by bovine leukemia virus. Gene expressions known as biomarkers of hematopoietic neoplasia in human were also examined in the present case. Increased messenger RNA expression of interleukin 2 receptor, thymidine kinase, and immunoglobulin-associated alpha-1 was observed in the case animal.
https://www.jstage.jst.go.jp/article/jvms/74/9/74_12-0100/_article/-char/ja/
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| Idioma: |
Inglês
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| Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/4096
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| Editor: |
日本獣医学会
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| Direitos: |
日本獣医学会
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