Sabiia Seb
        Busca avançada

Botão Atualizar

Botão Atualizar

Registro completo
Provedor de dados:  OAK
País:  Japan
Título:  Preliminary evaluation of oligomannose-coated liposome vaccines against lethal protozoan infections in mice
Autores:  Kuboki, Noritaka
Tiwananthagorn, Weerawan
Takagi, Hideaki
Nakayama, Tomoko
Xuan, Xuenan
Inoue, Noboru
Igarashi, Ikuo
Tsujimura, Kunio
Ikehara, Yuzuru
Kojima, Naoya
Yokoyama, Naoaki
Data:  2007-06
Ano:  2007
Palavras-chave:  Oligomannose-coated liposome (OML)
Soluble protozoan antigen
Antibody responses
Resumo:  The oligomannose-coated liposome (OML) vaccine is known to induce cellular immunity specific for the encapsulated antigen in immunized mice. In the present study, we preliminarily evaluated the effect of the OML vaccine encapsulating the soluble protozoan lysate of Toxoplasma gondii, Trypanosoma brucei gambiense, or Babesia rodhaini on the corresponding protozoan infections in mice. After the challenge of T. gondii, the OML vaccine group avoided the high mortality resulting from acute infection that was dominantly observed in other control groups. During the infectious course, the development of the T. gondii-specific antibody, which is an indicator of humoral immunity, was constantly controlled at a lower level in the surviving mice of the OML vaccine group than in other lethally affected mice. On the other hand, other OML vaccines targeting for T. b. gambiense and B. rodhaini did not show any effect on these lethal infections in mice. The present preliminary study suggests that OML is a novel vaccine tool, at least for the control of acute toxoplasmosis.
Idioma:  Inglês
Editor:  National Research Center for Protozoan Diseases
Formato:  application/pdf
Direitos:  National Research Center for Protozoan Diseases

Empresa Brasileira de Pesquisa Agropecuária - Embrapa
Todos os direitos reservados, conforme Lei n° 9.610
Política de Privacidade
Área restrita

Parque Estação Biológica - PqEB s/n°
Brasília, DF - Brasil - CEP 70770-901
Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC:

Valid HTML 4.01 Transitional