| Registro completo |
| Provedor de dados: |
OAK
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| País: |
Japan
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| Título: |
Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential
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| Autores: |
Adeyemi, Oluyomi Stephen
Murata, Yuho
Sugi, Tatsuki
Kato, Kentaro
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| Data: |
2017-02
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| Ano: |
2017
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| Palavras-chave: |
Antiparasite
Drug screening
Nanomedicine
Toxoplasmosis
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| Resumo: |
This study evaluated the anti-Toxoplasma gondii potential of gold, silver, and platinum nanoparticles (NPs). Inorganic NPs (0.01-1,000 mu g/mL) were screened for antiparasitic activity. The NPs caused >90% inhibition of T. gondii growth with EC50 values of <= 7, <= 1, and <= 100 mu g/mL for gold, silver, and platinum NPs, respectively. The NPs showed no host cell cytotoxicity at the effective anti-T. gondii concentrations; the estimated selectivity index revealed a >= 20-fold activity toward the parasite versus the host cell. The anti-T. gondii activity of the NPs, which may be linked to redox signaling, affected the parasite mitochondrial membrane potential and parasite invasion, replication, recovery, and infectivity potential. Our results demonstrated the antiparasitic potential of NPs. The findings support the further exploration of NPs as a possible source of alternative and effective anti-T. gondii agents.
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| Idioma: |
Inglês
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| Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/4450
info:doi/10.2147/IJN.S122178
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| Editor: |
Dove Medical Press
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| Direitos: |
This article is distributed under the terms of the Creative Commons Attribution - NonCommercial (BY-NC) 3.0 International License (http://creativecommons.org/licenses/by-nc/3.0/).
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