Registro completo |
Provedor de dados: |
OAK
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País: |
Japan
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Título: |
Vitamin C Deficiency Fails to Protect Mice from Malaria
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Autores: |
HERBAS, Maria Shirley
SUZUKI, Hiroshi
鈴木, 宏志
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Data: |
2010
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Ano: |
2010
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Palavras-chave: |
Free radical
Malaria
Vitamin C
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Resumo: |
Nutritional deficiencies are frequent in malaria-endemic areas. It seems that micronutrient antioxidants play an important role in malaria parasite’s proliferation. Thus, the effect of vitamin C deficiency on malaria infection was examined in mice. When vitamin C deficient mice, L-gulono-γ-lactone oxidase gene knockout mice which are unable to synthesize ascorbic acid, were infected with a lethal dose of Plasmodium berghei NK65-infected red blood cells, the knockout mice showed similar parasitemia kinetics and survival rates as wild-type mice. The results indicate that deficiency of vitamin C might not affect the development of the malaria parasite in mice.
http://www.jstage.jst.go.jp/article/expanim/59/2/59_239/_article/-char/ja/
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Idioma: |
Inglês
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Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/3016
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Editor: |
日本実験動物学会
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Formato: |
application/pdf
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Direitos: |
日本実験動物学会
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