| Registro completo |
| Provedor de dados: |
OMA
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| País: |
Belgium
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| Título: |
Drug assimilation in the tissue of European sea bass (<i>Dicentrarchus labrax</i>) fry delivered orally through bioencapsulation
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| Autores: |
Gapasin, R.S.J.
Nelis, H.
Chair, M.
Sorgeloos, P.
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| Data: |
1996
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| Ano: |
1996
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| Palavras-chave: |
Dicentrarchus labrax (Linnaeus
1758) [Bass]
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| Resumo: |
Assimilation levels of the antibacterials trimethoprim (TMP) and sulfamethoxazole (SMX) in sea bass (<i>Dicentrarchus labrax</i>) fry tissue administered orally were investigated. A 1:5 TMP and SMX combination incorporated in oil emulsion (Selco) at 20% and 40% concentrations (w/w) were bioencapsulated in <i>Artemia</i> (Instar II) nauplii. Chemotherapeutics-loaded ('medicated') nauplii were fed to the sea bass fry and drug concentration in the tissue were analysed by high-performance liquid chromatography (HPLC). Fish fed 40% 'medicated' <i>Artemia</i> assimilated significantly higher levels of chemotherapeutics compared with those fed 20% 'medicated' <i>Artemia</i> . Chemotherapeutics given at 40% reached peak levels (19.3 µg TMP/g DW and 23.31 µg SMX/g DW) within 2h while those at 20% peaked (8.74 µg TMP/g DW and 6.73 µg SMX/g DW) after 5h. TWP persisted in the tissues longer (up to 72h) than SMX (12-16h), suggesting a more efficient uptake and retention of the former and/or faster metabolism and elimination of the latter.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.vliz.be/nl/open-marien-archief?module=ref&refid=2964
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| Relação: |
info:eu-repo/semantics/altIdentifier/wos/A1996UK20900007
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| Fonte: |
%3Ci%3EJ.+Appl.+Ichthyol.+12%281%29%3C%2Fi%3E%3A+39-42.+%3Ca+href%3D%22https%3A%2F%2Fhdl.handle.net%2F10.1111%2Fj.1439-0426.1996.tb00057.x%22+target%3D%22_blank%22%3Ehttps%3A%2F%2Fhdl.handle.net%2F10.1111%2Fj.1439-0426.1996.tb00057.x%3C%2Fa%3E
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| Direitos: |
info:eu-repo/semantics/restrictedAccess
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