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Provedor de dados:  OMA
País:  Belgium
Título:  Live-food mediated drug delivery as a tool for disease treatment in larviculture: the enrichment of therapeutics in rotifers and <i>Artemia</i> nauplii
Autores:  Verpraet, R.
Chair, M.
Léger, P.
Nelis, H.
Sorgeloos, P.
De Leenheer, A.P.
Data:  1992
Ano:  1992
Palavras-chave:  Aquaculture systems
Disease control
Food chains
Resumo:  The live food enrichment technique using emulsions for nutritional deficiencies in rotifers and <i>Artemia</i> was further investigated as a tool for transferring therapeutics through the food chain. <i>Artemia</i> nauplii and the rotifer <i>Brachionus plicatilis</i> were enriched with a self-emulsifying concentrate in which the therapeutic mixture trimetoprim: sulfamethoxazole was incorporated. An analytical method and protocol for the quantification of trimethoprim and sulfamethoxazole in a heterogeneous biological matrix, such as <i>Artemia</i> , was developed using High Performance Liquid Chromatography. When applying a 24h enrichment period, the accumulation of both drugs in <i>Artemia</i> nauplii appeared to be linearly related to the concentration of the drugs in the enrichment product. Values of approximately 790 mg/kg of total drugs (protein basis; or 290 mg/kg on dry weight basis) could be obtained. In rotifers, the level of total therapeutics reached a value of about 116,mg/kg (protein basis) after 6h of enrichment. The ratio of the two drugs detected in rotifers was different from the one found in <i>Artemia</i> , suggesting different accumulation kinetics.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Fonte:  %3Ci%3EAquacult.+Eng.+11%3C%2Fi%3E%3A+133-139
Direitos:  info:eu-repo/semantics/restrictedAccess

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