| Registro completo |
| Provedor de dados: |
OMA
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| País: |
Belgium
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| Título: |
Live-food mediated drug delivery as a tool for disease treatment in larviculture: the enrichment of therapeutics in rotifers and <i>Artemia</i> nauplii
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| Autores: |
Verpraet, R.
Chair, M.
Léger, P.
Nelis, H.
Sorgeloos, P.
De Leenheer, A.P.
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| Data: |
1992
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| Ano: |
1992
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| Palavras-chave: |
Aquaculture systems
Disease control
Drugs
Food chains
Therapy
Artemia
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| Resumo: |
The live food enrichment technique using emulsions for nutritional deficiencies in rotifers and <i>Artemia</i> was further investigated as a tool for transferring therapeutics through the food chain. <i>Artemia</i> nauplii and the rotifer <i>Brachionus plicatilis</i> were enriched with a self-emulsifying concentrate in which the therapeutic mixture trimetoprim: sulfamethoxazole was incorporated. An analytical method and protocol for the quantification of trimethoprim and sulfamethoxazole in a heterogeneous biological matrix, such as <i>Artemia</i> , was developed using High Performance Liquid Chromatography. When applying a 24h enrichment period, the accumulation of both drugs in <i>Artemia</i> nauplii appeared to be linearly related to the concentration of the drugs in the enrichment product. Values of approximately 790 mg/kg of total drugs (protein basis; or 290 mg/kg on dry weight basis) could be obtained. In rotifers, the level of total therapeutics reached a value of about 116,mg/kg (protein basis) after 6h of enrichment. The ratio of the two drugs detected in rotifers was different from the one found in <i>Artemia</i> , suggesting different accumulation kinetics.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.vliz.be/nl/open-marien-archief?module=ref&refid=2894
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| Fonte: |
%3Ci%3EAquacult.+Eng.+11%3C%2Fi%3E%3A+133-139
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| Direitos: |
info:eu-repo/semantics/restrictedAccess
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