| Registro completo |
| Provedor de dados: |
AgEcon
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| País: |
United States
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| Título: |
A menu-driven facility for complex sample size calculation in randomized controlled trials with a survival or a binary outcome
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| Autores: |
Royston, Patrick
Babiker, Abdel
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| Data: |
2011-09-29
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| Ano: |
2002
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| Palavras-chave: |
Randomized controlled trials
Survival analysis
Logrank test
Experimental design
Research Methods/ Statistical Methods
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| Resumo: |
We present a menu-driven Stata program for the calculation of sample size or power for complex clinical trials with a survival time or a binary outcome. The features supported include up to six treatment arms, an arbitrary time-to-event distribution, fixed or time-varying hazard ratios, unequal patient allocation, loss to follow-up, staggered patient entry, and crossover of patients from their allocated treatment to an alternative treatment. The computations of sample size and power are based on the logrank test and are done according to the asymptotic distribution of the logrank test statistic, adjusted appropriately for the design features.
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| Tipo: |
Journal Article
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| Idioma: |
Inglês
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| Identificador: |
st0013
http://purl.umn.edu/115958
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| Relação: |
Stata Journal>Volume 2, Number 2, 2nd Quarter 2002
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| Formato: |
13
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