| Registro completo |
| Provedor de dados: |
Acta Toxicol. Argent.
|
| País: |
Argentina
|
| Título: |
Anticoagulant and factor Xa-like activities of Tityus discrepans scorpion venom
|
| Autores: |
Brazón,Josmary
Guerrero,Belsy
Suze,D
Sevcik, Carlos,Gina
Arocha-Piñango,Carmen L
|
| Data: |
2013-06-01
|
| Ano: |
2013
|
| Palavras-chave: |
Scorpion
Coagulation
Fibrinogen
Factor Xa
|
| Resumo: |
Tityus discrepans venom (TdV) produces a variety of haemostatic manifestations including alveoli fbrin deposition and/ or prothrombin and partial thromboplastin time (PT, PTT) alterations in mammals. In vitro studies have demonstrated that TdV contains tissue plasminogen activator-like (t-PA), fbrinolytic and plasmin inhibitory compounds and produces platelets activation through GPVI and a novel Src-dependent signalling pathway. The aim of this study is to describe the initial characterization of procoagulant and anticoagulant components from TdV. This venom was fractionated by exclusion molecular chromatography on a Sephadex G-50 column. The eluted material was collected as fve fractions called S1 to S5. These fractions and the whole venom were used to evaluate factor Xa- and thrombin-like activities, fbrinogen degradation, furthermore thrombin- and factor Xa-inhibitory activities. The results demonstrated that TdV contain components with factor Xa-like activity (procoagulants) as well fbrinogenolytic compounds present in the fraction S1 and components with factor Xa inhibitory activity in the fractions S4 and S5 (anticoagulants).
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432013000100003
|
| Editor: |
Asociación Toxicológica Argentina
|
| Formato: |
text/html
|
| Fonte: |
Acta toxicológica argentina v.21 n.1 2013
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
