| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities
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| Autores: |
MONTE,ZENAIDE S.
SILVA,AMANDA M.
LIMA,GLÁUCIA M.S.
SILVA,TERESINHA G. DA
MARQUES,KARLA M.R.
RODRIGUES,MARIA D.
FALCÃO,EMERSON P.S.
MELO,SEBASTIÃO J.
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| Data: |
2017-06-01
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| Ano: |
2017
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| Palavras-chave: |
Arylamidines
2D spectroscopy
Gram-negative bacteria
Yeast
Cytotoxicity
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| Resumo: |
ABSTRACT A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301051
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765201720160801
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.89 n.2 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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