| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Short and long period optimization of drug doses in the treatment of AIDS
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| Autores: |
CAETANO,MARCO A. L.
YONEYAMA,TAKASHI
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| Data: |
2002-09-01
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| Ano: |
2002
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| Palavras-chave: |
Modeling
Simulation
Drugs
Treatment
AIDS
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| Resumo: |
Numerical optimization techniques are useful in solving problems of computing the best inputs for systems described by mathematical models and when the objectives can be stated in a quantitative form. This work concerns the problem of optimizing the drug doses in the treatment of AIDS in terms of achieving a balance between the therapeutic response and the side effects. A mathematical model describing the dynamics of HIV viruses and CD4 cells is used to compute the short term optimal drug doses in the treatments of patients with AIDS by a direct method of optimization using a cost function of Bolza type. The model parameters were fitted to actual published clinical data. In order to simplify the numerical procedures, the control law is expressed as a series and the sub-optimal control is obtained by truncating the higher terms. When the patient reaches a clinically satisfactory state, the LQR - Linear Quadratic Regulator technique is used to determine the long period maintenance doses for the drugs. The doses computed using the LQR technique tend to be smaller than equivalent constant-dose therapy in terms of increase in the counts of CD4+T cells and reduction of the density of free viruses.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000300002
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/S0001-37652002000300002
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.74 n.3 2002
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| Direitos: |
info:eu-repo/semantics/openAccess
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