| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Inositol metabolism in Trypanosoma cruzi: potential target for chemotherapy against Chagas' disease
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| Autores: |
OLIVEIRA,MECIA M.
EINICKER-LAMAS,MARCELO
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| Data: |
2000-09-01
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| Ano: |
2000
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| Palavras-chave: |
Inositol
Trypanosoma cruzi
Chagas' disease
Chemotherapy
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| Resumo: |
Chagas' disease is a debilitating and often fatal disease caused by the protozoan parasite Trypanosoma cruzi. The great majority of surface molecules in trypanosomes are either inositol-containing phospholipids or glycoproteins that are anchored into the plasma membrane by glycosylphosphatidylinositol anchors. The polyalcohol myo-inositol is the precursor for the biosynthesis of these molecules. In this brief review, recent findings on some aspects of the molecular and cellular fate of inositol in T. cruzi life cycle are discussed and identified some points that could be targets for the development of parasite-specific therapeutic agents.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300015
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/S0001-37652000000300015
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.72 n.3 2000
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| Direitos: |
info:eu-repo/semantics/openAccess
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