| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk
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| Autores: |
COSTA-SILVA,DANYLO R.
BARROS-OLIVEIRA,MARIA DA CONCEIÇÃO
BORGES,RAFAEL S.
TAVARES,CLÉCITON B.
BORGES,UMBELINA S.
ALVES-RIBEIRO,FRANCISCO A.
SILVA,VLADIMIR C.
SILVA,BENEDITO B. DA
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| Data: |
2016-12-01
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| Ano: |
2016
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| Palavras-chave: |
Breast cancer
Risk factors
IGF-1
IGF-1 gene polymorphism
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| Resumo: |
ABSTRACT Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk. A growing number of studies support an association between IGF-1 gene polymorphism and breast cancer risk with conflicting results, nevertheless elucidation of the patterns of IGF-1 gene expression may permit characterization of women at high-risk for breast cancer, as well as the development of strategies for early diagnosis and efficient treatment against the disease.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602349
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765201620160169
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.88 n.4 2016
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| Direitos: |
info:eu-repo/semantics/openAccess
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