Registro completo |
Provedor de dados: |
Anais da ABC (AABC)
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País: |
Brazil
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Título: |
In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants
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Autores: |
Coy-Barrera,Ericsson D.
Cuca-Suarez,Luis E.
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Data: |
2011-12-01
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Ano: |
2011
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Palavras-chave: |
COX
Furofuran lignans
5-LOX
Ocotea macrophylla
Platelet aggregation
Pleurothyrium cinereum
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Resumo: |
The in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O--methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor and PAF-antagonist (COX-2 IC50 2.27 µM; 5-LOX IC50 5.05 µM; PAF IC50 2.51 µM). However, all compounds exhibited an activity at different levels, indicating good anti-inflammatory properties to be considered in further structural optimization studies.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000400026
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Editor: |
Academia Brasileira de Ciências
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Relação: |
10.1590/S0001-37652011005000044
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Formato: |
text/html
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Fonte: |
Anais da Academia Brasileira de Ciências v.83 n.4 2011
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Direitos: |
info:eu-repo/semantics/openAccess
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