| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Antifungal activity of the extracts and saponins from Sapindus saponaria L.
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| Autores: |
Tsuzuki,Joyce K.
Svidzinski,Terezinha I.E.
Shinobu,Cristiane S.
Silva,Luiz F.A.
Rodrigues-Filho,Edson
Cortez,Diógenes A.G.
Ferreira,Izabel C.P.
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| Data: |
2007-12-01
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| Ano: |
2007
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| Palavras-chave: |
Sapindaceae
Sapindus saponaria
Saponins
Antifungal activity
Candida
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| Resumo: |
Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis, C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extract was bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extract and one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separation of this fraction afforded two pure triterpene acetylated saponins: 3-O-(4-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-Lrhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl-hederagenin (1) and 3-O-(3,4-di-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabynopyranosyl-hederagenin (2). The structures of the compounds were based on spectral data (¹H and 13C NMR, HSQC, HMBC and MS), and on with literature. The saponins isolated showed strong activity against C. parapsilosis.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400002
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/S0001-37652007000400002
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.79 n.4 2007
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| Direitos: |
info:eu-repo/semantics/openAccess
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