| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Inhibitory effects on the production of inflammatory mediators and reactive oxygen species by Mori folium in lipopolysaccharide-stimulated macrophages and zebrafish
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| Autores: |
KWON,DA HYE
JEONG,JIN WOO
CHOI,EUN OK
LEE,HYE WON
LEE,KI WON
KIM,KI YOUNG
KIM,SUNG GOO
HONG,SU HYUN
KIM,GI-YOUNG
PARK,CHEOL
HWANG,HYE-JIN
SON,CHANG-GUE
CHOI,YUNG HYUN
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| Data: |
2017-05-01
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| Ano: |
2017
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| Palavras-chave: |
Mori folium
Inflammation
ROS
Macrophage
Zebrafish
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| Resumo: |
ABSTRACT Mori folium, the leaf of Morus alba L. (Moraceae), has been traditionally used for various medicinal purposes from ancient times to the present. In this study, we examined the effects of water extract of Mori folium (WEMF) on the production of inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2), and reactive oxygen species (ROS) in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages. Our data indicated that WEMF significantly suppressed the secretion of NO and PGE2 in RAW 264.7 macrophages without any significant cytotoxicity. The protective effects were accompanied by a marked reduction in their regulatory gene expression at the transcription level. WEMF attenuated LPS-induced intracellular ROS production in RAW 264.7 macrophages. It inhibited the nuclear translocation of the nuclear factor-kappa B p65 subunit and the activation of mitogen-activated protein kinases in LPS-treated RAW 264.7 macrophages. Furthermore, WEMF reduced LPS-induced NO production and ROS accumulation in zebrafish. Although more efforts are needed to fully understand the critical role of WEMF in the inhibition of inflammation, the findings of the present study may provide insights into the approaches for Mori folium as a potential therapeutic agent for inflammatory and antioxidant disorders.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200661
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765201720160836
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.89 n.1 suppl.0 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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