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Provedor de dados:  Anais da ABC (AABC)
País:  Brazil
Título:  Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review
Autores:  Ferreira,Paulo Michel P.
Costa-Lotufo,Leticia V.
Moraes,Manoel O.
Barros,Francisco W.A.
Martins,Aline M.A.
Cavalheiro,Alberto J.
Bolzani,Vanderlan S.
Santos,Andre G.
Data:  2011-12-01
Ano:  2011
Palavras-chave:  Casearia sylvestris
Folk uses
Pharmacological properties
Resumo:  Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this work was to review the pharmacological properties of C. sylvestris, emphasizing its anti-ulcer, anti-inflammatory, anti-ophidian and antitumor potentialities. Ethanolic extracts and essential oil of their leaves have antiulcerogenic activity and reduce gastric volume without altering the stomach pH, which corroborates their consumption on gastrointestinal disorders. Leaf water extracts show phospholipase A2 inhibitory activity that prevents damage effects on the muscular tissue after toxin inoculation. This antiphospholipasic action is probably related to the use as an anti-inflammatory, proposing a pharmacological blockage similar to that obtained with non-steroidal anti-inflammatory drugs on arachidonic acid and cyclooxygenase pathways. Bioguided-assay fractionations lead to the identification of secondary metabolites, especially the clerodane diterpenes casearins (A-X) and casearvestrins (A-C), compounds with a remarkable cytotoxic and antitumor action. Therefore, the C. sylvestris shrub holds a known worldwide pharmacological arsenal by its extensive folk utilization, exciting searches for new molecules and a better comprehension about biological properties.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Academia Brasileira de Ciências
Relação:  10.1590/S0001-37652011005000040
Formato:  text/html
Fonte:  Anais da Academia Brasileira de Ciências v.83 n.4 2011
Direitos:  info:eu-repo/semantics/openAccess

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