Registro completo |
Provedor de dados: |
Biocell
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País: |
Argentina
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Título: |
Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allum cepa root model
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Autores: |
Sehgal,R.
Roy,S.
Kumar,V.L.
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Data: |
2006-04-01
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Ano: |
2006
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Palavras-chave: |
Calotropis procera
Podophyllotoxin
Cyclophosphamide
Cytotoxic
Allium cepa
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Resumo: |
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cytotoxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000100002
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Editor: |
Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
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Formato: |
text/html
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Fonte: |
Biocell v.30 n.1 2006
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Direitos: |
info:eu-repo/semantics/openAccess
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