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Provedor de dados:  47
País:  Argentina
Título:  Genotoxic effect of Physalis angulata L. (Solanaceae) extract on human lymphocytes treated in vitro
Autores:  Alves dos Santos,Raquel
Cabral,Teresinha Rosa
Cabral,Isabel Rosa
Greggi Antunes,Lusânia Maria
Pontes Andrade,Cristiane
Cerqueira dos Santos Cardoso,Plínio
de Oliveira Bahia,Marcelo
Pessoa,Claudia
Martins do Nascimento,José Luis
Rodríguez Burbano,Rommel
Satie Takahashi,Catarina
Data:  2008-08-01
Ano:  2008
Palavras-chave:  P. angulata
Micronuclei
Comet assay
Resumo:  Physalis angulata L (Solanaceae) is a medicinal plant from North of Brazil, whose different extracts and infusions are commonly used in the popular medicine for the treatment of malaria, asthma, hepatitis, dermatitis and rheumatism. However, the genotoxic effects of P. angulata on human cells is not well known. The main purpose of the present study was to evaluate the in vitro genotoxic effects of aqueous extract of P. angulata using the comet assay and the micronucleus assay in human lymphocytes provided from 6 healthy donors. Treatments with P. angulata extracts were performed in vitro in order to access the extent of DNA damage. The comet assay has shown that treatments with P. angulata at 0.5, 1.0, 2.0, 3.0 and 6.0 &#956;g/mL in culture medium were genotoxic. Lymphocytes treated with P. angulata at the concentrations of 3.0 and 6.0&#956;g/mL in culture medium showed a statistically significant increase in the frequency of micronucleus (p<0.05), however, the cytokinesis blocked proliferation index (CBPI) was not decreased after P. angulata treatment. In conclusion, the present work demonstrated the genotoxic effects of P. angulata extract on human lymphocytes in vitro.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200005
Editor:  Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
Formato:  text/html
Fonte:  Biocell v.32 n.2 2008
Direitos:  info:eu-repo/semantics/openAccess
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