| Registro completo |
| Provedor de dados: |
Biocell
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| País: |
Argentina
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| Título: |
Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells
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| Autores: |
Hong,Samin
Park,Kyoungsoo
Kim,Chan Yun
Seong,Gong Je
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| Data: |
2008-08-01
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| Ano: |
2008
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| Palavras-chave: |
Retinal ganglion cell
Tumor necrosis factor-alpha
Hypoxia
Agmatine
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| Resumo: |
The effect of hypoxia on the release of tumor necrosis factor-alpha (TNF-alpha) in transformed rat retinal ganglion cells (RGCs) and the effect of agmatine on the hypoxia-induced production of TNF-alpha in RGCs were evaluated. RGCs were cultured under hypoxic conditions with 5% oxygen, with or without 100μM agmatine. The expression levels of TNF-alpha and its receptor-1 (TNF-R1) were investigated by Western blot analysis. After 6 hours of hypoxia, we noted an increase in TNF-alpha production in RGCs. Agmatine significantly reduced TNF-alpha level after 12 hours of hypoxic treatment. The expression of TNF-R1 was not affected by the hypoxia or agmatine treatment. Our results show that agmatine inhibits the TNF-alpha production of RGCs in hypoxic condition. These results demonstrate a possible neuroprotective mechanism for agmatine against hypoxic damage in RGCs.
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| Tipo: |
Info:eu-repo/semantics/other
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200006
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| Editor: |
Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
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| Formato: |
text/html
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| Fonte: |
Biocell v.32 n.2 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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