| Registro completo |
| Provedor de dados: |
Biol. Res.
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| País: |
Chile
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| Título: |
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology
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| Autores: |
Nualart,Francisco
Salazar,Katterine
Oyarce,Karina
Cisternas,Pedro
Jara,Nery
Silva-Álvarez,Carmen
Pastor,Patricia
Martínez,Fernando
García,Andrea
García-Robles,María de los Ángeles
Tapia,Juan Carlos
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| Data: |
2012-01-01
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| Ano: |
2012
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| Palavras-chave: |
Stem cells
Radial glia
Vitamin C
SVCT2
Brain development
Tanycytes
Bergmann glia
Neurogenic niche
Type B cells
Neuroblast
Parkinson's disease
Alzheimer's disease
Amyotrophic lateral sclerosis
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| Resumo: |
Stem cells are considered a valuable cellular resource for tissue replacement therapies in most brain disorders. Stem cells have the ability to self-replicate and differentiate into numerous cell types, including neurons, oligodendrocytes and astrocytes. As a result, stem cells have been considered the "holy grail" of modern medical neuroscience. Despite their tremendous therapeutic potential, little is known about the mechanisms that regulate their differentiation. In this review, we analyze stem cells in embryonic and adult brains, and illustrate the differentiation pathways that give origin to most brain cells. We also evaluate the emergent role of the well known anti-oxidant, vitamin C, in stem cell differentiation. We believe that a complete understanding of all molecular players, including vitamin C, in stem cell differentiation will positively impact on the use of stem cell transplantation for neurodegenerative diseases.
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| Tipo: |
Journal article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300006
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| Editor: |
Sociedad de Biología de Chile
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| Formato: |
text/html
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| Fonte: |
Biological Research v.45 n.3 2012
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