| Registro completo |
| Provedor de dados: |
Biol. Res.
|
| País: |
Chile
|
| Título: |
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
|
| Autores: |
GALARCE,GLORIA D
FONCEA,ROCÍO E
EDWARDS,ANA M
PESSOA-MAHANA,HERNÁN
PESSOA-MAHANA,CARLOS D
EBENSPERGER,ROBERTO A
|
| Data: |
2008-01-01
|
| Ano: |
2008
|
| Palavras-chave: |
Anti-inflammatory agents
Benzimidazoquinazoline derivatives
TNF-á inhibitors
|
| Resumo: |
This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents
|
| Tipo: |
Journal article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006
|
| Editor: |
Sociedad de Biología de Chile
|
| Formato: |
text/html
|
| Fonte: |
Biological Research v.41 n.1 2008
|
|
