Registro completo |
Provedor de dados: |
Biol. Res.
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País: |
Chile
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Título: |
Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies
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Autores: |
LIU,X
HINTZE,K
LONNERDAL,B
THEIL,EC
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Data: |
2006-01-01
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Ano: |
2006
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Resumo: |
Bioiron _ central to respiration, photosynthesis and DNA synthesis and complicated by radical chemistry with oxygen _ depends on ferritin, the super family of protein nanocages (maxi-ferritins in humans, animals, plants and bacteria, and mini-ferritins, also called DPS proteins, in bacteria) for iron and oxygen control. Regulation of ferritin synthesis, best studied in animals, uses DNA transcription and mRNA translation check points. Ferritin is a member of both the "oxidant stress response" gene family that includes thioredoxin reductase and quinine reductase, and a member of the iron responsive gene family that includes ferroportin and mt-aconitase ferritin DNA regulation responds preferentially to oxidant response inducers and ferritin mRNA to iron inducers; heme confers regulator synergy. Ferritin proteins manage iron and oxygen, with ferroxidase sites and iron + oxygen substrates to form mineral of both Fe and O atoms; maxi-ferritins contribute more to cellular iron metabolism and mini-ferritins to stress responses. Iron recovery from ferritin is controlled by gated protein pores, possibly contributing to iron absorption from ferritin, a significant dietary iron source. Ferritin gene regulation is a model for integrating DNA/mRNA controls, while ferritin protein function is central to molecular nutrition cellular metabolism at the crossroads of iron and oxygen in biology
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Tipo: |
Journal article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100018
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Editor: |
Sociedad de Biología de Chile
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Formato: |
text/html
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Fonte: |
Biological Research v.39 n.1 2006
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