| Registro completo |
| Provedor de dados: |
Biol. Res.
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| País: |
Chile
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| Título: |
Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
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| Autores: |
LINHARES,JOSÉ JUVENAL
GUERREIRO DA SILVA,ISMAEL DALE COTRIM
NOGUEIRA DE SOUZA,NAIARA C
COELHO NORONHA,EMMANUELLE
FERRARO,ODAIR
DE CARVALHO,CRISTINA VALLETA
CHADA BARACAT,EDMUND
FARAH BARACAT,FAUSTO
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| Data: |
2005-01-01
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| Ano: |
2005
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| Palavras-chave: |
Breast cancer
Genetic polymorphisms
GSTM1
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| Resumo: |
Due to the conflicting results regarding the association between breast cancerand the GSTM1 null mutation, our aim was to research this associationin a Brazilian population and correlations withsmoking, reproductive history and several clinical pathologies. A case-control study was performed on 105 women with breast cancer and 278 controls. Extraction of DNA was accomplished according to the protocol of the GFX® kit and polymorphism analysis by the PCR technique. The control and experimental groups were compared and statistical analysis assessed by X² or Fisher's exact test. The deletion in the GSTM1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. In the control group, the null mutation was present in 104 (37.4%) women. Upon comparison of the two groups, no statistically significant difference of the GSTM1 gene was observed, with an odds ratio (OR) of 0.74, 95%, confidence interval (CI) 0.45 - 1.20, p = 0.277. The results conclusively show that singlegene GSTM1 polymorphisms do not confer a substantial risk of breastcancer to its carriers. Furthermore, in this study no correlation was found between GSTs andsmoking, reproductive history and several clinical pathologies with respect to cancer risk.
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| Tipo: |
Journal article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200017
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| Editor: |
Sociedad de Biología de Chile
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| Formato: |
text/html
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| Fonte: |
Biological Research v.38 n.2-3 2005
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