| Registro completo |
| Provedor de dados: |
Biota Neotropica
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| País: |
Brazil
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| Título: |
Screening of Brazilian plants for antimicrobial and dnadamaging activities: I. Atlantic rain forest . Ecological station juréia-itatins
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| Autores: |
Agripino,Débora Gomes
Lima,Marcos Enoque Leite
Silva,Marcelo Rogério da
Meda,Cristiane Infante
Bolzani,Vanderlan da Silva
Cordeiro,Inês
Young,Maria Claudia Marx
Moreno,Paulo Roberto H.
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| Data: |
2004-01-01
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| Ano: |
2004
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| Palavras-chave: |
Atlantic Rain forest
Antibacterial activity
Antifungal activity
Antitumoral activity
Plants screening
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| Resumo: |
I. Atlantic Rain Forest . Ecological Station Juréia-Itatins) Crude extracts from 88 plant species occurring in São Paulo State (Brazil), collected in an Atlantic Forest region, have been screened for antimicrobial and DNA-damaging activities. Of the 114 extracts assayed for antibacterial activity, only the extracts from leaves and stems of Aspidosperma ramiflorum (Apocynaceae) showed a slight activity against Escherichia coli. In the antifungal assay with Candida albicans, no active extract was observed, while in the bioautography assay with Cladosporium sphaerospermum and C. cladosporioides 12% were active. However, only the extract of Psychotria mapoureoides (Rubiaceae) stems showed a strong inhibition of both fungi. The DNA-damaging assay with mutant strains of Saccharomyces cerevisiae resulted in 17.5 % of active extracts. The majority (55 %) of the active extracts showed selectivity for the DNA-repair mechanism of topoisomerase II and only 20 % showed a selective response for the mechanism of topoisomerase I.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032004000200009
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| Editor: |
Instituto Virtual da Biodiversidade | BIOTA - FAPESP
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| Relação: |
10.1590/S1676-06032004000200009
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| Formato: |
text/html
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| Fonte: |
Biota Neotropica v.4 n.2 2004
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| Direitos: |
info:eu-repo/semantics/openAccess
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