| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Pinnatoxins’ Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health
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| Autores: |
Delcourt, Nicolas
Lagrange, Emmeline
Abadie, Eric
Fessard, Valérie
Frémy, Jean-marc
Vernoux, Jean-paul
Peyrat, Marie-bénédicte
Maignien, Thomas
Arnich, Nathalie
Molgó, Jordi
Mattei, César
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| Data: |
2019-07
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| Ano: |
2019
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| Palavras-chave: |
Pinnatoxins
Cyclic imines
Vulcanodinium rugosum
Nicotinic acetylcholine receptors
Acute neurotoxicity
Human intoxication
Myasthenia gravis
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| Resumo: |
Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been reported to date although acute toxicity was induced by PnTxs in rodents. LD50 values have been estimated for the different PnTXs through the oral route. At sublethal doses, all symptoms are reversible, and no neurological sequelae are visible. These symptoms are consistent with impairment of central and peripheral cholinergic network functions. In fact, PnTXs are high-affinity competitive antagonists of nicotinic acetylcholine receptors (nAChRs). Moreover, their lethal effects are consistent with the inhibition of muscle nAChRs, inducing respiratory distress and paralysis. Human intoxication by ingestion of PnTXs could result in various symptoms observed in episodes of poisoning with natural nAChR antagonists. This review updates the available data on PnTX toxicity with a focus on their mode of action on cholinergic networks and suggests the effects that could be extrapolated on human physiology.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00507/61883/65958.pdf
DOI:10.3390/md17070425
https://archimer.ifremer.fr/doc/00507/61883/
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| Editor: |
MDPI AG
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| Formato: |
application/pdf
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| Fonte: |
Marine Drugs (1660-3397) (MDPI AG), 2019-07 , Vol. 17 , N. 7 , P. 425 (13p.)
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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