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Provedor de dados:  ArchiMer
País:  France
Título:  Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells
Autores:  Hughes, Kristelle
Ho, Raimana
Greff, Stéphane
Filaire, Edith
Ranouille, Edwige
Chazaud, Claire
Herbette, Gaëtan
Butaud, Jean-françois
Berthon, Jean-yves
Raharivelomanana, Phila
Data:  2020-10
Ano:  2020
Palavras-chave:  Polynesian plants
Dermal papilla
Hair growth
Resumo:  Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth
Tipo:  Text
Idioma:  Inglês

Editor:  MDPI AG
Formato:  application/pdf
Fonte:  Molecules (1420-3049) (MDPI AG), 2020-10 , Vol. 25 , N. 19 , P. 4360 (19p.)
Direitos:  info:eu-repo/semantics/openAccess

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