| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia
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| Autores: |
Aimond, Axelle
Calabro, Kevin
Audoin, Coralie
Olivier, Elodie
Dutot, Mélody
Buron, Pauline
Rat, Patrice
Laprévote, Olivier
Prado, Soizic
Roulland, Emmanuel
Thomas, Olivier P.
Genta-jouve, Grégory
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| Data: |
2020-02
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| Ano: |
2020
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| Palavras-chave: |
Sideritis hyssopifolia
Ent-kaurane
Anti-inflammatory
NMR
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| Resumo: |
This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00610/72214/71012.pdf
https://archimer.ifremer.fr/doc/00610/72214/71013.pdf
DOI:10.3390/molecules25030589
https://archimer.ifremer.fr/doc/00610/72214/
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| Editor: |
MDPI AG
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| Formato: |
application/pdf
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| Fonte: |
Molecules (1420-3049) (MDPI AG), 2020-02 , Vol. 25 , N. 3 , P. 589 (10p.)
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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