| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Evolution of gene dosage on the Z-chromosome of schistosome parasites
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| Autores: |
Picard, Marion A. L.
Cosseau, Celine
Ferre, Sabrina
Quack, Thomas
Grevelding, Christoph G.
Coute, Yohann
Vicoso, Beatriz
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| Data: |
2018-07
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| Ano: |
2018
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| Resumo: |
XY systems usually show chromosome-wide compensation of X-linked genes, while in many ZW systems, compensation is restricted to a minority of dosage-sensitive genes. Why such differences arose is still unclear. Here, we combine comparative genomics, transcriptomics and proteomics to obtain a complete overview of the evolution of gene dosage on the Z-chromosome of Schistosoma parasites. We compare the Z-chromosome gene content of African (Schistosoma mansoni and S. haematobium) and Asian (S. japonicum) schistosomes and describe lineage-specific evolutionary strata. We use these to assess gene expression evolution following sex-linkage. The resulting patterns suggest a reduction in expression of Z-linked genes in females, combined with upregulation of the Z in both sexes, in line with the first step of Ohno's classic model of dosage compensation evolution. Quantitative proteomics suggest that post-transcriptional mechanisms do not play a major role in balancing the expression of Z-linked genes.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00454/56588/71845.pdf
DOI:10.7554/eLife.35684
https://archimer.ifremer.fr/doc/00454/56588/
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| Editor: |
Elife Sciences Publications Ltd
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| Formato: |
application/pdf
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| Fonte: |
Elife (2050-084X) (Elife Sciences Publications Ltd), 2018-07 , Vol. 7 , N. e35684 , P. 36p.
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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