| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action
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| Autores: |
Vignet, Caroline
Larcher, Thibaut
Davail, Blandine
Joassard, Lucette
Le Menach, Karyn
Guionnet, Tiphaine
Lyphout, Laura
Ledevin, Mireille
Goubeau, Manon
Budzinski, Helene
Begout, Marie-laure
Cousin, Xavier
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| Data: |
2016-12
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| Ano: |
2016
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| Palavras-chave: |
Polycyclic aromatic hydrocarbons
Zebrafish
Spawning success
Fertilization
Gonad differentiation
Molecular mechanisms
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| Resumo: |
Polycyclic aromatic hydrocarbons (PAHs) constitute a large family of organic pollutants emitted in the environment as complex mixtures, the compositions of which depend on origin. Among a wide range of physiological defects, PAHs are suspected to be involved in disruption of reproduction. In an aquatic environment, the trophic route is an important source of chronic exposure to PAHs. Here, we performed trophic exposure of zebrafish to three fractions of different origin, one pyrolytic and two petrogenic. Produced diets contained PAHs at environmental concentrations. Reproductive traits were analyzed at individual, tissue and molecular levels. Reproductive success and cumulative eggs number were disrupted after exposure to all three fractions, albeit to various extents depending on the fraction and concentrations. Histological analyses revealed ovary maturation defects after exposure to all three fractions as well as degeneration after exposure to a pyrolytic fraction. In testis, hypoplasia was observed after exposure to petrogenic fractions. Genes expression analysis in gonads has allowed us to establish common pathways such as endocrine disruption or differentiation/maturation defects. Taken altogether, these results indicate that PAHs can indeed disrupt fish reproduction and that different fractions trigger different pathways resulting in different effects.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00355/46641/46465.pdf
https://archimer.ifremer.fr/doc/00355/46641/46466.pdf
DOI:10.3390/toxics4040026
https://archimer.ifremer.fr/doc/00355/46641/
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| Editor: |
Mdpi Ag
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| Formato: |
application/pdf
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| Fonte: |
Toxics (2305-6304) (Mdpi Ag), 2016-12 , Vol. 4 , N. 4 , P. 26 (1-18)
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| Direitos: |
2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
info:eu-repo/semantics/openAccess
restricted use
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